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Directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval

INTRODUCTION: Spatial working memory is a kind of short-term memory that allows temporarily storing and manipulating spatial information. Evidence suggests that spatial working memory is processed through three distinctive phases: Encoding, maintenance, and retrieval. Though the medial prefrontal co...

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Autores principales: Wang, Jia, Zhang, Shengnan, Liu, Tiaotiao, Zheng, Xuyuan, Tian, Xin, Bai, Wenwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726760/
https://www.ncbi.nlm.nih.gov/pubmed/36507330
http://dx.doi.org/10.3389/fnins.2022.1055986
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author Wang, Jia
Zhang, Shengnan
Liu, Tiaotiao
Zheng, Xuyuan
Tian, Xin
Bai, Wenwen
author_facet Wang, Jia
Zhang, Shengnan
Liu, Tiaotiao
Zheng, Xuyuan
Tian, Xin
Bai, Wenwen
author_sort Wang, Jia
collection PubMed
description INTRODUCTION: Spatial working memory is a kind of short-term memory that allows temporarily storing and manipulating spatial information. Evidence suggests that spatial working memory is processed through three distinctive phases: Encoding, maintenance, and retrieval. Though the medial prefrontal cortex (mPFC) and mediodorsal thalamus (MD) are involved in memory retrieval, how the functional interactions and information transfer between mPFC and MD remains largely unclear. METHODS: We recorded local field potentials (LFPs) from mPFC and MD while mice performed a spatial working memory task in T-maze. The temporal dynamics of functional interactions and bidirectional information flow between mPFC and MD was quantitatively assessed by using directed transfer function. RESULTS: Our results showed a significantly elevated information flow from mPFC to MD, varied in time and frequency (theta in particular), accompanying successful memory retrieval. DISCUSSION: Elevated theta information flow, a feature that was absent on error trials, indicates an important role of the directional information transfer from mPFC to MD for memory retrieval.
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spelling pubmed-97267602022-12-08 Directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval Wang, Jia Zhang, Shengnan Liu, Tiaotiao Zheng, Xuyuan Tian, Xin Bai, Wenwen Front Neurosci Neuroscience INTRODUCTION: Spatial working memory is a kind of short-term memory that allows temporarily storing and manipulating spatial information. Evidence suggests that spatial working memory is processed through three distinctive phases: Encoding, maintenance, and retrieval. Though the medial prefrontal cortex (mPFC) and mediodorsal thalamus (MD) are involved in memory retrieval, how the functional interactions and information transfer between mPFC and MD remains largely unclear. METHODS: We recorded local field potentials (LFPs) from mPFC and MD while mice performed a spatial working memory task in T-maze. The temporal dynamics of functional interactions and bidirectional information flow between mPFC and MD was quantitatively assessed by using directed transfer function. RESULTS: Our results showed a significantly elevated information flow from mPFC to MD, varied in time and frequency (theta in particular), accompanying successful memory retrieval. DISCUSSION: Elevated theta information flow, a feature that was absent on error trials, indicates an important role of the directional information transfer from mPFC to MD for memory retrieval. Frontiers Media S.A. 2022-11-23 /pmc/articles/PMC9726760/ /pubmed/36507330 http://dx.doi.org/10.3389/fnins.2022.1055986 Text en Copyright © 2022 Wang, Zhang, Liu, Zheng, Tian and Bai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Jia
Zhang, Shengnan
Liu, Tiaotiao
Zheng, Xuyuan
Tian, Xin
Bai, Wenwen
Directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval
title Directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval
title_full Directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval
title_fullStr Directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval
title_full_unstemmed Directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval
title_short Directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval
title_sort directional prefrontal-thalamic information flow is selectively required during spatial working memory retrieval
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726760/
https://www.ncbi.nlm.nih.gov/pubmed/36507330
http://dx.doi.org/10.3389/fnins.2022.1055986
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