Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status

ABSTRACT: Deoxycytidine kinase (dCK) and 5’ deoxynucleotidase (NT5C2) are involved in metabolism of cladribine (2CdA), the immunomodulatory drug for multiple sclerosis; by mediating phosphorylation (activation) or phosphorolysis (deactivation) of 2CdA, respectively, these enzymes promote or prevent...

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Detalles Bibliográficos
Autores principales: Carlini, Federico, Ivaldi, Federico, Gualandi, Francesca, Boschert, Ursula, Centonze, Diego, Matarese, Giuseppe, Salvetti, Marco, Kerlero de Rosbo, Nicole, Uccelli, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726780/
https://www.ncbi.nlm.nih.gov/pubmed/33851318
http://dx.doi.org/10.1007/s11481-021-09994-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726780/
https://www.ncbi.nlm.nih.gov/pubmed/33851318
http://dx.doi.org/10.1007/s11481-021-09994-3

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