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Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents

7-Ethyl-10-hydroxycamptothecin (SN38), a highly potent metabolite of irinotecan, has an anticancer efficacy 100–1000 folds more than irinotecan in vitro. However, the clinical application of SN38 has been limited due to the very narrow therapeutic window and poor water solubility. Herein, we report...

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Detalles Bibliográficos
Autores principales:	Yang, Chao, Xia, An-Jie, Du, Cheng-Hao, Hu, Ming-Xing, Gong, You-Ling, Tian, Rong, Jiang, Xin, Xie, Yong-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726873/ https://www.ncbi.nlm.nih.gov/pubmed/36506586 http://dx.doi.org/10.3389/fphar.2022.1014854

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