MDMX elevation by a novel Mdmx–p53 interaction inhibitor mitigates neuronal damage after ischemic stroke

Mdmx and Mdm2 are two major suppressor factors for the tumor suppressor gene p53. In central nervous system, Mdmx suppresses the transcriptional activity of p53 and enhances the binding of Mdm2 to p53 for degradation. But Mdmx dynamics in cerebral infarction remained obscure. Here we investigated th...

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Detalles Bibliográficos
Autores principales: Yan, Haomin, Sasaki, Tsutomu, Kanki, Hideaki, Hirata, Yoshiyuki, Nishiyama, Kumiko, Hisada, Sunao, Matsumura, Shigenobu, Nagaoka, Yasuo, Sumiyoshi, Takaaki, Nagano, Seiichi, Nakata, Akiko, Yoshida, Minoru, Uesato, Shinichi, Mochizuki, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726886/
https://www.ncbi.nlm.nih.gov/pubmed/36473920
http://dx.doi.org/10.1038/s41598-022-25427-4

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