SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing

The glycolytic enzyme, pyruvate kinase Pyk1 maintains telomere heterochromatin by phosphorylating histone H3T11 (H3pT11), which promotes SIR (silent information regulator) complex binding at telomeres and prevents autophagy-mediated Sir2 degradation. However, the exact mechanism of action for H3pT11...

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Detalles Bibliográficos
Autores principales: He, Fei, Yu, Qi, Wang, Min, Wang, Rongsha, Gong, Xuanyunjing, Ge, Feng, Yu, Xilan, Li, Shanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726891/
https://www.ncbi.nlm.nih.gov/pubmed/36473858
http://dx.doi.org/10.1038/s41467-022-35182-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726891/
https://www.ncbi.nlm.nih.gov/pubmed/36473858
http://dx.doi.org/10.1038/s41467-022-35182-9

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