Impact of SNPs, off-targets, and passive permeability on efficacy of BCL6 degrading drugs assigned by virtual screening and 3D-QSAR approach

B-cell lymphoma 6 (BCL6) regulates various genes and is reported to be overexpressed in lymphomas and other malignancies. Thus, BCL6 inhibition or its tagging for degradation would be an amenable therapeutic approach. A library of 2500 approved drugs was employed to find BCL6 inhibitory molecules vi...

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Detalles Bibliográficos
Autores principales: Karimi, Solmaz, Shahabi, Farzaneh, Mubarak, Shaden M. H., Arjmandi, Hanie, Hashemi, Zahra Sadat, Pourzardosht, Navid, Zakeri, Alireza, Mahboobi, Mahdieh, Jahangiri, Abolfazl, Rahbar, Mohammad Reza, Khalili, Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726907/
https://www.ncbi.nlm.nih.gov/pubmed/36473934
http://dx.doi.org/10.1038/s41598-022-25587-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726907/
https://www.ncbi.nlm.nih.gov/pubmed/36473934
http://dx.doi.org/10.1038/s41598-022-25587-3

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