Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma

BACKGROUND: The patients with dual oesophageal squamous cell carcinoma (ESCC) and hypopharyngeal cancer (HPC) have poor prognosis; their underlying genetic pathogenesis is unclear. We hypothesise that development of synchronous ESCC/HPC depends on multicentricity or independent origin, rather than m...

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Detalles Bibliográficos
Autores principales: Ko, Josephine Mun-Yee, Guo, Chen, Liu, Conghui, Ning, Lvwen, Dai, Wei, Tao, Lihua, Lo, Anthony Wing-Ip, Wong, Carissa Wing-Yan, Wong, Ian Yu-Hong, Chan, Fion Siu-Yin, Wong, Claudia Lai-Yin, Chan, Kwan Kit, Law, Tsz Ting, Lee, Nikki Pui-Yue, Liu, Zhichao, Jiang, Haoyao, Li, Zhigang, Law, Simon, Lung, Maria Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726980/
https://www.ncbi.nlm.nih.gov/pubmed/36261585
http://dx.doi.org/10.1038/s41416-022-01995-0

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