Cargando…
Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine
BACKGROUND: Arterial stiffness is a major risk factor and effective predictor of cardiovascular diseases and a common pathway of pathological vascular impairments. Homocysteine (Hcy) and uric acid (UA) own the shared metabolic pathways to affect vascular function. Serum uric acid (UA) has a great im...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727018/ https://www.ncbi.nlm.nih.gov/pubmed/36505895 http://dx.doi.org/10.1007/s13167-022-00298-x |
_version_ | 1784844918362996736 |
---|---|
author | Wu, Zhiyuan Zhang, Haiping Li, Zhiwei Li, Haibin Miao, Xinlei Pan, Huiying Wang, Jinqi Liu, Xiangtong Kang, Xiaoping Li, Xia Tao, Lixin Guo, Xiuhua |
author_facet | Wu, Zhiyuan Zhang, Haiping Li, Zhiwei Li, Haibin Miao, Xinlei Pan, Huiying Wang, Jinqi Liu, Xiangtong Kang, Xiaoping Li, Xia Tao, Lixin Guo, Xiuhua |
author_sort | Wu, Zhiyuan |
collection | PubMed |
description | BACKGROUND: Arterial stiffness is a major risk factor and effective predictor of cardiovascular diseases and a common pathway of pathological vascular impairments. Homocysteine (Hcy) and uric acid (UA) own the shared metabolic pathways to affect vascular function. Serum uric acid (UA) has a great impact on arterial stiffness and cardiovascular risk, while the mutual effect with Hcy remains unknown yet. This study aimed to evaluate the mutual effect of serum Hcy and UA on arterial stiffness and 10-year cardiovascular risk in the general population. From the perspective of predictive, preventive, and personalized medicine (PPPM/3PM), we assumed that combined assessment of Hcy and UA provides a better tool for targeted prevention and personalized intervention of cardiovascular diseases via suppressing arterial stiffness. METHODS: This study consisted of 17,697 participants from Beijing Health Management Cohort, who underwent health examination between January 2012 and December 2019. Brachial-ankle pulse wave velocity (baPWV) was used as an index of arterial stiffness. RESULTS: Individuals with both high Hcy and UA had the highest baPWV, compared with those with low Hcy and low UA (β: 30.76, 95% CI: 18.36–43.16 in males; β: 53.53, 95% CI: 38.46–68.60 in females). In addition, these individuals owned the highest 10-year cardiovascular risk (OR: 1.49, 95% CI: 1.26–1.76 in males; OR: 7.61, 95% CI: 4.63–12.68 in females). Of note, males with high homocysteine and low uric acid were significantly associated with increased cardiovascular risk (OR: 1.30, 95% CI: 1.15–1.47), but not the high uric acid and low homocysteine group (OR: 1.02, 95% CI: 0.90–1.16). CONCLUSIONS: This study found the significantly mutual effect of Hcy and UA on arterial stiffness and cardiovascular risk using a large population and suggested the clinical importance of combined evaluation and control of Hcy and UA for promoting cardiovascular health. The adverse effect of homocysteine on arteriosclerosis should be addressed beyond uric acid, especially for males. Monitoring of the level of both Hcy and UA provides a window opportunity for PPPM/3PM in the progression of arterial stiffness and prevention of CVD. Hcy provides a novel predictor beyond UA of cardiovascular health to identify individuals at high risk of arterial stiffness for the primary prevention and early treatment of CVD. In the progressive stage of arterial stiffness, active control of Hcy and UA levels from the aspects of dietary behavior and medication treatment is conducive to alleviating the level of arterial stiffness and reducing the risk of CVD. Further studies are needed to evaluate the clinical effect of Hcy and UA targeted intervention on arterial stiffness and cardiovascular health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13167-022-00298-x. |
format | Online Article Text |
id | pubmed-9727018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-97270182022-12-08 Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine Wu, Zhiyuan Zhang, Haiping Li, Zhiwei Li, Haibin Miao, Xinlei Pan, Huiying Wang, Jinqi Liu, Xiangtong Kang, Xiaoping Li, Xia Tao, Lixin Guo, Xiuhua EPMA J Research BACKGROUND: Arterial stiffness is a major risk factor and effective predictor of cardiovascular diseases and a common pathway of pathological vascular impairments. Homocysteine (Hcy) and uric acid (UA) own the shared metabolic pathways to affect vascular function. Serum uric acid (UA) has a great impact on arterial stiffness and cardiovascular risk, while the mutual effect with Hcy remains unknown yet. This study aimed to evaluate the mutual effect of serum Hcy and UA on arterial stiffness and 10-year cardiovascular risk in the general population. From the perspective of predictive, preventive, and personalized medicine (PPPM/3PM), we assumed that combined assessment of Hcy and UA provides a better tool for targeted prevention and personalized intervention of cardiovascular diseases via suppressing arterial stiffness. METHODS: This study consisted of 17,697 participants from Beijing Health Management Cohort, who underwent health examination between January 2012 and December 2019. Brachial-ankle pulse wave velocity (baPWV) was used as an index of arterial stiffness. RESULTS: Individuals with both high Hcy and UA had the highest baPWV, compared with those with low Hcy and low UA (β: 30.76, 95% CI: 18.36–43.16 in males; β: 53.53, 95% CI: 38.46–68.60 in females). In addition, these individuals owned the highest 10-year cardiovascular risk (OR: 1.49, 95% CI: 1.26–1.76 in males; OR: 7.61, 95% CI: 4.63–12.68 in females). Of note, males with high homocysteine and low uric acid were significantly associated with increased cardiovascular risk (OR: 1.30, 95% CI: 1.15–1.47), but not the high uric acid and low homocysteine group (OR: 1.02, 95% CI: 0.90–1.16). CONCLUSIONS: This study found the significantly mutual effect of Hcy and UA on arterial stiffness and cardiovascular risk using a large population and suggested the clinical importance of combined evaluation and control of Hcy and UA for promoting cardiovascular health. The adverse effect of homocysteine on arteriosclerosis should be addressed beyond uric acid, especially for males. Monitoring of the level of both Hcy and UA provides a window opportunity for PPPM/3PM in the progression of arterial stiffness and prevention of CVD. Hcy provides a novel predictor beyond UA of cardiovascular health to identify individuals at high risk of arterial stiffness for the primary prevention and early treatment of CVD. In the progressive stage of arterial stiffness, active control of Hcy and UA levels from the aspects of dietary behavior and medication treatment is conducive to alleviating the level of arterial stiffness and reducing the risk of CVD. Further studies are needed to evaluate the clinical effect of Hcy and UA targeted intervention on arterial stiffness and cardiovascular health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13167-022-00298-x. Springer International Publishing 2022-09-26 /pmc/articles/PMC9727018/ /pubmed/36505895 http://dx.doi.org/10.1007/s13167-022-00298-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Wu, Zhiyuan Zhang, Haiping Li, Zhiwei Li, Haibin Miao, Xinlei Pan, Huiying Wang, Jinqi Liu, Xiangtong Kang, Xiaoping Li, Xia Tao, Lixin Guo, Xiuhua Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine |
title | Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine |
title_full | Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine |
title_fullStr | Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine |
title_full_unstemmed | Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine |
title_short | Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine |
title_sort | mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727018/ https://www.ncbi.nlm.nih.gov/pubmed/36505895 http://dx.doi.org/10.1007/s13167-022-00298-x |
work_keys_str_mv | AT wuzhiyuan mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT zhanghaiping mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT lizhiwei mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT lihaibin mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT miaoxinlei mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT panhuiying mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT wangjinqi mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT liuxiangtong mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT kangxiaoping mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT lixia mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT taolixin mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine AT guoxiuhua mutualeffectofhomocysteineanduricacidonarterialstiffnessandcardiovascularriskinthecontextofpredictivepreventiveandpersonalizedmedicine |