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Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)

Yersinia enterocolitica is a Gram-negative bacterium that typical results in enterocolitis in humans and poses significant worldwide risks to public health. An outbreak of yersiniosis in the Vervet/African green monkey colony at the WFSM during the winter of 2015–2016 accounted for widespread system...

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Autores principales: Balamayooran, Gayathriy, Atkins, Hannah M., Andrews, Rachel N., Michalson, Kristofer T., Hutchison, A. Robert, LeGrande, Andre C., Wilson, Quentin N., Gee, Melaney K., Aycock, S. Tyler, Jorgensen, Matthew J., Young, Richard W., Kock, Nancy D., Caudell, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727084/
https://www.ncbi.nlm.nih.gov/pubmed/36504866
http://dx.doi.org/10.3389/fvets.2022.922961
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author Balamayooran, Gayathriy
Atkins, Hannah M.
Andrews, Rachel N.
Michalson, Kristofer T.
Hutchison, A. Robert
LeGrande, Andre C.
Wilson, Quentin N.
Gee, Melaney K.
Aycock, S. Tyler
Jorgensen, Matthew J.
Young, Richard W.
Kock, Nancy D.
Caudell, David L.
author_facet Balamayooran, Gayathriy
Atkins, Hannah M.
Andrews, Rachel N.
Michalson, Kristofer T.
Hutchison, A. Robert
LeGrande, Andre C.
Wilson, Quentin N.
Gee, Melaney K.
Aycock, S. Tyler
Jorgensen, Matthew J.
Young, Richard W.
Kock, Nancy D.
Caudell, David L.
author_sort Balamayooran, Gayathriy
collection PubMed
description Yersinia enterocolitica is a Gram-negative bacterium that typical results in enterocolitis in humans and poses significant worldwide risks to public health. An outbreak of yersiniosis in the Vervet/African green monkey colony at the WFSM during the winter of 2015–2016 accounted for widespread systemic infection with high morbidity and mortality. Most of the cases had extensive necrosis with suppuration and large colonies of bacilli in the large bowel and associated lymph nodes; however, the small intestine, stomach, and other organs were also regularly affected. Positive cultures of Yersinia enterocolitica were recovered from affected tissues in 20 of the 23 cases. Carrier animals in the colony were suspected as the source of the infection because many clinically normal animals were culture-positive during and after the outbreak. In this study, we describe the gross and histology findings and immune cell profiles in different organs of affected animals. We found increased numbers of myeloid-derived phagocytes and CD11C-positive antigen-presenting cells and fewer adaptive T and B lymphocytes, suggesting an immunocompromised state in these animals. The pathogen-mediated microenvironment may have contributed to the immunosuppression and rapid spread of the infection in the vervets. Further studies in vervets could provide a better understanding of Yersinia-mediated pathogenesis and immunosuppression, which could be fundamental to understanding chronic and systemic inflammatory diseases in humans.
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spelling pubmed-97270842022-12-08 Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus) Balamayooran, Gayathriy Atkins, Hannah M. Andrews, Rachel N. Michalson, Kristofer T. Hutchison, A. Robert LeGrande, Andre C. Wilson, Quentin N. Gee, Melaney K. Aycock, S. Tyler Jorgensen, Matthew J. Young, Richard W. Kock, Nancy D. Caudell, David L. Front Vet Sci Veterinary Science Yersinia enterocolitica is a Gram-negative bacterium that typical results in enterocolitis in humans and poses significant worldwide risks to public health. An outbreak of yersiniosis in the Vervet/African green monkey colony at the WFSM during the winter of 2015–2016 accounted for widespread systemic infection with high morbidity and mortality. Most of the cases had extensive necrosis with suppuration and large colonies of bacilli in the large bowel and associated lymph nodes; however, the small intestine, stomach, and other organs were also regularly affected. Positive cultures of Yersinia enterocolitica were recovered from affected tissues in 20 of the 23 cases. Carrier animals in the colony were suspected as the source of the infection because many clinically normal animals were culture-positive during and after the outbreak. In this study, we describe the gross and histology findings and immune cell profiles in different organs of affected animals. We found increased numbers of myeloid-derived phagocytes and CD11C-positive antigen-presenting cells and fewer adaptive T and B lymphocytes, suggesting an immunocompromised state in these animals. The pathogen-mediated microenvironment may have contributed to the immunosuppression and rapid spread of the infection in the vervets. Further studies in vervets could provide a better understanding of Yersinia-mediated pathogenesis and immunosuppression, which could be fundamental to understanding chronic and systemic inflammatory diseases in humans. Frontiers Media S.A. 2022-11-23 /pmc/articles/PMC9727084/ /pubmed/36504866 http://dx.doi.org/10.3389/fvets.2022.922961 Text en Copyright © 2022 Balamayooran, Atkins, Andrews, Michalson, Hutchison, LeGrande, Wilson, Gee, Aycock, Jorgensen, Young, Kock and Caudell. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Balamayooran, Gayathriy
Atkins, Hannah M.
Andrews, Rachel N.
Michalson, Kristofer T.
Hutchison, A. Robert
LeGrande, Andre C.
Wilson, Quentin N.
Gee, Melaney K.
Aycock, S. Tyler
Jorgensen, Matthew J.
Young, Richard W.
Kock, Nancy D.
Caudell, David L.
Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)
title Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)
title_full Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)
title_fullStr Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)
title_full_unstemmed Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)
title_short Epizootic Yersinia enterocolitica in captive African green monkeys (Chlorocebus aethiops sabaeus)
title_sort epizootic yersinia enterocolitica in captive african green monkeys (chlorocebus aethiops sabaeus)
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727084/
https://www.ncbi.nlm.nih.gov/pubmed/36504866
http://dx.doi.org/10.3389/fvets.2022.922961
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