Primary resistance to first- and second-generation ALK inhibitors in a non-small cell lung cancer patient with coexisting ALK rearrangement and an ALK F1174L-cis-S1189C de novo mutation: A case report

The effectiveness of the tyrosine kinase inhibitor ALK (TKI) for non-small cell lung cancer has been confirmed. However, resistance to ALK-TKIs seems inevitable. Mutations in the ALK kinase domain have been reported as an important mechanism of acquired resistance to ALK therapy. However, patients w...

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Detalles Bibliográficos
Autores principales: Zhao, Jiuzhou, Li, Xiang, Fan, Ruizhe, Qin, Yaping, Wang, Zhizhong, Wang, Bo, Li, Shaomei, Fan, Jianfeng, Wu, Xinxin, Liu, Hongxia, Guan, Yuping, Liang, Yinfeng, Zhang, Xiao, Guo, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727108/
https://www.ncbi.nlm.nih.gov/pubmed/36506539
http://dx.doi.org/10.3389/fphar.2022.1060460

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