Roles and mechanisms of CircRNAs in ovarian cancer

Ovarian cancer (OC) is one of the female malignancies with nearly 45% 5-year survival rate. Circular RNAs (circRNAs), a kind of single-stranded non-coding RNAs, are generated from the back-splicing of cellular housekeeping noncoding RNAs and precursor messenger RNAs. Recent studies revealed that cir...

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Autores principales: Liu, Min, Cao, Siyu, Guo, Ziyi, Wu, Zong, Meng, Jiao, Wu, Yong, Shao, Yang, Li, Yanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727202/
https://www.ncbi.nlm.nih.gov/pubmed/36506086
http://dx.doi.org/10.3389/fcell.2022.1044897
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author Liu, Min
Cao, Siyu
Guo, Ziyi
Wu, Zong
Meng, Jiao
Wu, Yong
Shao, Yang
Li, Yanli
author_facet Liu, Min
Cao, Siyu
Guo, Ziyi
Wu, Zong
Meng, Jiao
Wu, Yong
Shao, Yang
Li, Yanli
author_sort Liu, Min
collection PubMed
description Ovarian cancer (OC) is one of the female malignancies with nearly 45% 5-year survival rate. Circular RNAs (circRNAs), a kind of single-stranded non-coding RNAs, are generated from the back-splicing of cellular housekeeping noncoding RNAs and precursor messenger RNAs. Recent studies revealed that circRNAs have different biological function, including sponging miRNAs, encoding micropeptides, regulating stability of cytoplasmic mRNAs, affecting transcription and splicing, via interacting with DNA, RNA and proteins. Due to their stability, circRNAs have the potential of acting as biomarkers and treatment targets. In this review, we briefly illustrate the biogenesis mechanism and biological function of circRNAs in OC, and make a perspective of circRNAs drug targeting immune responses and signaling pathways in OC. This article can provide a systematic view into the current situation and future of circRNAs in OC.
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spelling pubmed-97272022022-12-08 Roles and mechanisms of CircRNAs in ovarian cancer Liu, Min Cao, Siyu Guo, Ziyi Wu, Zong Meng, Jiao Wu, Yong Shao, Yang Li, Yanli Front Cell Dev Biol Cell and Developmental Biology Ovarian cancer (OC) is one of the female malignancies with nearly 45% 5-year survival rate. Circular RNAs (circRNAs), a kind of single-stranded non-coding RNAs, are generated from the back-splicing of cellular housekeeping noncoding RNAs and precursor messenger RNAs. Recent studies revealed that circRNAs have different biological function, including sponging miRNAs, encoding micropeptides, regulating stability of cytoplasmic mRNAs, affecting transcription and splicing, via interacting with DNA, RNA and proteins. Due to their stability, circRNAs have the potential of acting as biomarkers and treatment targets. In this review, we briefly illustrate the biogenesis mechanism and biological function of circRNAs in OC, and make a perspective of circRNAs drug targeting immune responses and signaling pathways in OC. This article can provide a systematic view into the current situation and future of circRNAs in OC. Frontiers Media S.A. 2022-11-23 /pmc/articles/PMC9727202/ /pubmed/36506086 http://dx.doi.org/10.3389/fcell.2022.1044897 Text en Copyright © 2022 Liu, Cao, Guo, Wu, Meng, Wu, Shao and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Min
Cao, Siyu
Guo, Ziyi
Wu, Zong
Meng, Jiao
Wu, Yong
Shao, Yang
Li, Yanli
Roles and mechanisms of CircRNAs in ovarian cancer
title Roles and mechanisms of CircRNAs in ovarian cancer
title_full Roles and mechanisms of CircRNAs in ovarian cancer
title_fullStr Roles and mechanisms of CircRNAs in ovarian cancer
title_full_unstemmed Roles and mechanisms of CircRNAs in ovarian cancer
title_short Roles and mechanisms of CircRNAs in ovarian cancer
title_sort roles and mechanisms of circrnas in ovarian cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727202/
https://www.ncbi.nlm.nih.gov/pubmed/36506086
http://dx.doi.org/10.3389/fcell.2022.1044897
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