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Phase I trial of pembrolizumab plus vemurafenib and cobimetinib in patients with metastatic melanoma

BACKGROUND: Preclinical and translational evidence suggest BRAF/MEK inhibitors modulate the tumor microenvironment (TME), providing rationale for combination with immunotherapy. METHODS: This investigator-initiated, phase I trial evaluated pembrolizumab, vemurafenib, and cobimetinib in patients with...

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Detalles Bibliográficos
Autores principales:	Shaikh, Saba S., Zang, Yan, Hanmer, Janel, Wang, Hong, Lin, Yan, Davar, Diwakar, Zarour, Hassane M., Kirkwood, John M., Najjar, Yana G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727229/ https://www.ncbi.nlm.nih.gov/pubmed/36505793 http://dx.doi.org/10.3389/fonc.2022.1022496

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