Cargando…
Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study
BACKGROUND: Growing evidence has shown the association between vitamin E intake and the risk of cognitive decline, but the conclusions were inconsistent. This study aimed to verify the hypothesis that vitamin E intake is associated with incident dementia and deterioration of global cognition. MATERI...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727246/ https://www.ncbi.nlm.nih.gov/pubmed/36505244 http://dx.doi.org/10.3389/fnut.2022.1036795 |
_version_ | 1784844970507632640 |
---|---|
author | Liu, Su Luo, Jianfeng Xiao, Zhenxu Wu, Wanqing Liang, Xiaoniu Ding, Saineng Zhao, Qianhua Zhao, Xianfeng Wang, Yi Ding, Ding |
author_facet | Liu, Su Luo, Jianfeng Xiao, Zhenxu Wu, Wanqing Liang, Xiaoniu Ding, Saineng Zhao, Qianhua Zhao, Xianfeng Wang, Yi Ding, Ding |
author_sort | Liu, Su |
collection | PubMed |
description | BACKGROUND: Growing evidence has shown the association between vitamin E intake and the risk of cognitive decline, but the conclusions were inconsistent. This study aimed to verify the hypothesis that vitamin E intake is associated with incident dementia and deterioration of global cognition. MATERIALS AND METHODS: We followed 1,550 non-demented community residents aged ≥60 years for an average of 5.2 years in the Shanghai Aging Study. Baseline vitamin E intake were measured by the Food Frequency Questionnaire. Cognitive function was evaluated by a battery of neuropsychological tests. Consensus diagnosis of incident dementia was made based on the DSM-IV criteria. RESULTS: During the follow-up, 135 cases (8.7%) of incident dementia were identified. The incidence rates of dementia in low, low-medium, medium-high, and high vitamin E intake groups were 2.8, 1.5, 1.6, and 0.7 per 100 person-years, respectively (P < 0.001). Participants with low vitamin E intake had a significantly higher risk of incident dementia than those with higher intake [compared with the highest intake group: hazard ratio (HR) 2.34, 95% confidence interval (CI) 1.20–4.57] after adjusting for confounders. Vitamin E intake was negatively correlated to the rate of annual decline of Mini-Mental State Examination score with the adjustment of confounders (β = 0.019, p = 0.001). CONCLUSION: Vitamin E intake is negatively correlated with the risk of dementia in older adults. An appropriate high amount of vitamin E intake from the diet might be helpful to prevent future cognitive decline. |
format | Online Article Text |
id | pubmed-9727246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97272462022-12-08 Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study Liu, Su Luo, Jianfeng Xiao, Zhenxu Wu, Wanqing Liang, Xiaoniu Ding, Saineng Zhao, Qianhua Zhao, Xianfeng Wang, Yi Ding, Ding Front Nutr Nutrition BACKGROUND: Growing evidence has shown the association between vitamin E intake and the risk of cognitive decline, but the conclusions were inconsistent. This study aimed to verify the hypothesis that vitamin E intake is associated with incident dementia and deterioration of global cognition. MATERIALS AND METHODS: We followed 1,550 non-demented community residents aged ≥60 years for an average of 5.2 years in the Shanghai Aging Study. Baseline vitamin E intake were measured by the Food Frequency Questionnaire. Cognitive function was evaluated by a battery of neuropsychological tests. Consensus diagnosis of incident dementia was made based on the DSM-IV criteria. RESULTS: During the follow-up, 135 cases (8.7%) of incident dementia were identified. The incidence rates of dementia in low, low-medium, medium-high, and high vitamin E intake groups were 2.8, 1.5, 1.6, and 0.7 per 100 person-years, respectively (P < 0.001). Participants with low vitamin E intake had a significantly higher risk of incident dementia than those with higher intake [compared with the highest intake group: hazard ratio (HR) 2.34, 95% confidence interval (CI) 1.20–4.57] after adjusting for confounders. Vitamin E intake was negatively correlated to the rate of annual decline of Mini-Mental State Examination score with the adjustment of confounders (β = 0.019, p = 0.001). CONCLUSION: Vitamin E intake is negatively correlated with the risk of dementia in older adults. An appropriate high amount of vitamin E intake from the diet might be helpful to prevent future cognitive decline. Frontiers Media S.A. 2022-11-23 /pmc/articles/PMC9727246/ /pubmed/36505244 http://dx.doi.org/10.3389/fnut.2022.1036795 Text en Copyright © 2022 Liu, Luo, Xiao, Wu, Liang, Ding, Zhao, Zhao, Wang and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Liu, Su Luo, Jianfeng Xiao, Zhenxu Wu, Wanqing Liang, Xiaoniu Ding, Saineng Zhao, Qianhua Zhao, Xianfeng Wang, Yi Ding, Ding Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study |
title | Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study |
title_full | Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study |
title_fullStr | Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study |
title_full_unstemmed | Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study |
title_short | Low dietary vitamin E intake is associated with high risk of incident dementia among older adults: The Shanghai Aging Study |
title_sort | low dietary vitamin e intake is associated with high risk of incident dementia among older adults: the shanghai aging study |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727246/ https://www.ncbi.nlm.nih.gov/pubmed/36505244 http://dx.doi.org/10.3389/fnut.2022.1036795 |
work_keys_str_mv | AT liusu lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT luojianfeng lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT xiaozhenxu lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT wuwanqing lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT liangxiaoniu lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT dingsaineng lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT zhaoqianhua lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT zhaoxianfeng lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT wangyi lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy AT dingding lowdietaryvitamineintakeisassociatedwithhighriskofincidentdementiaamongolderadultstheshanghaiagingstudy |