The interplay between non-coding RNAs and Wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis

Non-coding RNAs (ncRNAs) are emerging as important regulators in various pathological conditions including tumorigenesis, metastasis, and drug resistance in human cancers. Oncogenic or tumor suppressor ncRNAs exert prominent effects on cell proliferation, migration and invasion in cancer cells throu...

Descripción completa

Detalles Bibliográficos
Autores principales: Rahmani, Farzad, Safavi, Pegah, Fathollahpour, Ayda, Tanhaye Kalate Sabz, Fatemeh, Tajzadeh, Parastoo, Arefnezhad, Mohsen, Ferns, Gordon A., Hassanian, Seyed Mahdi, Avan, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727268/
https://www.ncbi.nlm.nih.gov/pubmed/36483915
http://dx.doi.org/10.17179/excli2022-5348
_version_ 1784844976296820736
author Rahmani, Farzad
Safavi, Pegah
Fathollahpour, Ayda
Tanhaye Kalate Sabz, Fatemeh
Tajzadeh, Parastoo
Arefnezhad, Mohsen
Ferns, Gordon A.
Hassanian, Seyed Mahdi
Avan, Amir
author_facet Rahmani, Farzad
Safavi, Pegah
Fathollahpour, Ayda
Tanhaye Kalate Sabz, Fatemeh
Tajzadeh, Parastoo
Arefnezhad, Mohsen
Ferns, Gordon A.
Hassanian, Seyed Mahdi
Avan, Amir
author_sort Rahmani, Farzad
collection PubMed
description Non-coding RNAs (ncRNAs) are emerging as important regulators in various pathological conditions including tumorigenesis, metastasis, and drug resistance in human cancers. Oncogenic or tumor suppressor ncRNAs exert prominent effects on cell proliferation, migration and invasion in cancer cells through modulating various signaling pathways including Wnt/β-catenin. Upregulation of the oncogenic Wnt/β-catenin pathway was reported to be implicated in multiple human cancers including breast, liver, colorectal, and urothelial cancers. Therefore, identifying interactions between ncRNAs and canonical Wnt signaling components may represent novel therapeutic targets for better treatment and management of cancer. In this review, we summarized the recent findings about miRNA/lncRNA-dependent mechanisms that regulate Wnt/β-catenin signaling involved in tumorigenesis and metastasis of urinary tract cancers.
format Online
Article
Text
id pubmed-9727268
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Leibniz Research Centre for Working Environment and Human Factors
record_format MEDLINE/PubMed
spelling pubmed-97272682022-12-07 The interplay between non-coding RNAs and Wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis Rahmani, Farzad Safavi, Pegah Fathollahpour, Ayda Tanhaye Kalate Sabz, Fatemeh Tajzadeh, Parastoo Arefnezhad, Mohsen Ferns, Gordon A. Hassanian, Seyed Mahdi Avan, Amir EXCLI J Review Article Non-coding RNAs (ncRNAs) are emerging as important regulators in various pathological conditions including tumorigenesis, metastasis, and drug resistance in human cancers. Oncogenic or tumor suppressor ncRNAs exert prominent effects on cell proliferation, migration and invasion in cancer cells through modulating various signaling pathways including Wnt/β-catenin. Upregulation of the oncogenic Wnt/β-catenin pathway was reported to be implicated in multiple human cancers including breast, liver, colorectal, and urothelial cancers. Therefore, identifying interactions between ncRNAs and canonical Wnt signaling components may represent novel therapeutic targets for better treatment and management of cancer. In this review, we summarized the recent findings about miRNA/lncRNA-dependent mechanisms that regulate Wnt/β-catenin signaling involved in tumorigenesis and metastasis of urinary tract cancers. Leibniz Research Centre for Working Environment and Human Factors 2022-10-18 /pmc/articles/PMC9727268/ /pubmed/36483915 http://dx.doi.org/10.17179/excli2022-5348 Text en Copyright © 2022 Rahmani et al. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Review Article
Rahmani, Farzad
Safavi, Pegah
Fathollahpour, Ayda
Tanhaye Kalate Sabz, Fatemeh
Tajzadeh, Parastoo
Arefnezhad, Mohsen
Ferns, Gordon A.
Hassanian, Seyed Mahdi
Avan, Amir
The interplay between non-coding RNAs and Wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis
title The interplay between non-coding RNAs and Wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis
title_full The interplay between non-coding RNAs and Wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis
title_fullStr The interplay between non-coding RNAs and Wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis
title_full_unstemmed The interplay between non-coding RNAs and Wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis
title_short The interplay between non-coding RNAs and Wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis
title_sort interplay between non-coding rnas and wnt/ß-catenin signaling pathway in urinary tract cancers: from tumorigenesis to metastasis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727268/
https://www.ncbi.nlm.nih.gov/pubmed/36483915
http://dx.doi.org/10.17179/excli2022-5348
work_keys_str_mv AT rahmanifarzad theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT safavipegah theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT fathollahpourayda theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT tanhayekalatesabzfatemeh theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT tajzadehparastoo theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT arefnezhadmohsen theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT fernsgordona theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT hassanianseyedmahdi theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT avanamir theinterplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT rahmanifarzad interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT safavipegah interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT fathollahpourayda interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT tanhayekalatesabzfatemeh interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT tajzadehparastoo interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT arefnezhadmohsen interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT fernsgordona interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT hassanianseyedmahdi interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis
AT avanamir interplaybetweennoncodingrnasandwntßcateninsignalingpathwayinurinarytractcancersfromtumorigenesistometastasis

Ejemplares similares