Cargando…

Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT116 as a Surrogate Model Colorectal Carcinoma

BACKGROUND: Colorectal carcinoma (CRC) represents life-threatening problems worldwide. IQ motif containing GTPase activating protein 1 (IQGAP1) is acting as oncogenesis regulators. RNAi is proposed as promising cancer therapeutics. OBJECTIVE: The objective of this work to explore the consequences of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zoheir, Khairy M A, Mahmoud, Khaled, Harisa, Gamaleldin I., Ashour, Abdelkader, Abdel-Hamied, Hala E., Amara, Amro A., Mahrous, Karima F., Abd-Rabou, Ahmed A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	West Asia Organization for Cancer Prevention 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727335/ https://www.ncbi.nlm.nih.gov/pubmed/35901346 http://dx.doi.org/10.31557/APJCP.2022.23.7.2387

Ejemplares similares

Inhibition of induced-hepatic cancer in vivo through IQGAP1-shRNA gene therapy and modulation of TRAIL-induced apoptosis pathway
por: Zoheir, Khairy M. A., et al.
Publicado: (2022)

New Approach about the Signaling Crosstalk between IQGAPs/NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma
por: Zoheir, Khairy M A, et al.
Publicado: (2022)

Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro
por: Dong, Pei-Xin, et al.
Publicado: (2008)

Chitosan treatment abrogates hypercholesterolemia-induced erythrocyte’s arginase activation
por: Harisa, Gamaleldin I., et al.
Publicado: (2017)

Inhibitory effects of adenovirus mediated tandem expression of RhoA and RhoC shRNAs in HCT116 cells
por: Liu, Xiang-ping, et al.
Publicado: (2009)

Construction of shRNA lentiviral vector
por: Song, Hong, et al.
Publicado: (2010)

Optimized PCR Conditions and Increased shRNA Fold Representation Improve Reproducibility of Pooled shRNA Screens
por: Strezoska, Žaklina, et al.
Publicado: (2012)

Procaine Induces Epigenetic Changes in HCT116 Colon Cancer Cells
por: Sabit, Hussein, et al.
Publicado: (2016)

Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines
por: Chowdhury, Sanjib, et al.
Publicado: (2013)

Transcriptome comparisons detect new genes associated with apoptosis of cattle and buffaloes preantral follicles
por: Zoheir, Khairy Mohamed, et al.
Publicado: (2021)

shRNA target prediction informed by comprehensive enquiry (SPICE): a supporting system for high-throughput screening of shRNA library
por: Kamatuka, Kenta, et al.
Publicado: (2016)

Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design
por: Matveeva, Olga V., et al.
Publicado: (2010)

Improved siRNA/shRNA Functionality by Mismatched Duplex
por: Wu, Haoquan, et al.
Publicado: (2011)

Resistin and Visfatin Expression in HCT-116 Colorectal Cancer Cell Line
por: Ghaemmaghami, Sara, et al.
Publicado: (2013)

Characterization of sphere-forming HCT116 clones by whole RNA sequencing
por: Chung, Eunkyung, et al.
Publicado: (2016)

Entrainment of superoxide rhythm by menadione in HCT116 colon cancer cells
por: Kizhuveetil, Uma, et al.
Publicado: (2019)

Suppression of Cancer Progression by MGAT1 shRNA Knockdown
por: Beheshti Zavareh, Reza, et al.
Publicado: (2012)

IQGAP1 Is a Phosphotyrosine-Regulated Scaffold for SH2-Containing Proteins
por: Thines, Louise, et al.
Publicado: (2023)

Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
por: Abd-Rabou, Ahmed A, et al.
Publicado: (2017)

Optimization and characterization of tRNA-shRNA expression constructs
por: Scherer, Lisa J., et al.
Publicado: (2007)

Design and cloning strategies for constructing shRNA expression vectors
por: McIntyre, Glen J, et al.
Publicado: (2006)

The effects of stem length and core placement on shRNA activity
por: Mcintyre, Glen J, et al.
Publicado: (2011)

Energy profile and secondary structure impact shRNA efficacy
por: Zhou, Hong, et al.
Publicado: (2009)

Production of Transgenic Calves Expressing an shRNA Targeting Myostatin
por: Tessanne, K, et al.
Publicado: (2012)

Using shRNA experiments to validate gene regulatory networks
por: Olsen, Catharina, et al.
Publicado: (2015)

Silencing Human Rb2/p130 with shRNA
por: Leucci, Eleonora, et al.
Publicado: (2007)

Stable expression of shRNA for the control of recombinant adenovirus replication
por: Lana, M.V.G., et al.
Publicado: (2023)

Specific properties of shRNA-mediated CCR5 downregulation that enhance the inhibition of HIV-1 infection in combination with shRNA targeting HIV-1 rev
por: Cardona, Maria E., et al.
Publicado: (2022)

Criteria for effective design, construction, and gene knockdown by shRNA vectors
por: Taxman, Debra J, et al.
Publicado: (2006)

Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell
por: Park, Dong-Guk
Publicado: (2014)

Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines
por: PAKDEMİRLİ, Ahu, et al.
Publicado: (2020)

The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA
por: Lisowski, Leszek, et al.
Publicado: (2013)

IQGAP1 and IQGAP2 are Reciprocally Altered in Hepatocellular Carcinoma
por: White, Colin D, et al.
Publicado: (2010)

Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cells
por: As Sobeai, Homood M., et al.
Publicado: (2022)

Single copy shRNA configuration for ubiquitous gene knockdown in mice
por: Seibler, Jost, et al.
Publicado: (2005)

PCR-based generation of shRNA libraries from cDNAs
por: Du, Cheng, et al.
Publicado: (2006)

Letter to the editor: Does Dicer Expression Affect shRNA processing?
por: Senzer, Neil, et al.
Publicado: (2009)

Nucleic acid aptamers for targeting of shRNA-based cancer therapeutics
por: Vorhies, John S, et al.
Publicado: (2007)

A comparison of multiple shRNA expression methods for combinatorial RNAi
por: Mcintyre, Glen J, et al.
Publicado: (2011)

ShRNA-Targeted COMMD7 Suppresses Hepatocellular Carcinoma Growth
por: Zheng, Lu, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qdi1erat0scilrp8mrv1ehgjdg