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Combined Blockade Of PD-1 and TIGIT is not Sufficient to Improve the Function Of CD8+ T-Cells in Chronic Lymphocytic Leukemia

BACKGROUND AND OBJECTIVE: Blockade of immune checkpoint receptors in the treatment of cancers has been mentioned in several studies. Here, we investigated the efficacy of combined blockade of two inhibitory receptors, PD-1 and TIGIT, in restoring functional features of CD8+ T-cells in CLL. METHODS:...

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Detalles Bibliográficos
Autores principales:	Hatefi, Fatemeh, Asgarian-Omran, Hossein, Hossein-Nattaj, Hadi, Akbar, Armin, Shekarriz, Ramin, Zaboli, Ehsan, Janbabaei, Ghasem, Tehrani, Mohsen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	West Asia Organization for Cancer Prevention 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727349/ https://www.ncbi.nlm.nih.gov/pubmed/35901326 http://dx.doi.org/10.31557/APJCP.2022.23.7.2225

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