Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis

Mechanisms regulating neurogenesis involve broad and complex processes that represent intriguing therapeutic targets in the field of regenerative medicine. One influential factor guiding neural stem cell proliferation and cellular differentiation during neurogenesis are epigenetic mechanisms. We pre...

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Detalles Bibliográficos
Autores principales: Rhodes, Christopher T., Lin, Chin-Hsing Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727419/
https://www.ncbi.nlm.nih.gov/pubmed/36018148
http://dx.doi.org/10.4103/1673-5374.350188
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author Rhodes, Christopher T.
Lin, Chin-Hsing Annie
author_facet Rhodes, Christopher T.
Lin, Chin-Hsing Annie
author_sort Rhodes, Christopher T.
collection PubMed
description Mechanisms regulating neurogenesis involve broad and complex processes that represent intriguing therapeutic targets in the field of regenerative medicine. One influential factor guiding neural stem cell proliferation and cellular differentiation during neurogenesis are epigenetic mechanisms. We present an overview of epigenetic mechanisms including chromatin structure and histone modifications; and discuss novel roles of two histone modifiers, Ezh2 and Suv4-20h1/Suv4-20h2 (collectively referred to as Suv4-20h), in neurodevelopment and neurogenesis. This review will focus on broadly reviewing epigenetic regulatory components, the roles of epigenetic components during neurogenesis, and potential applications in regenerative medicine.
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spelling pubmed-97274192022-12-08 Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis Rhodes, Christopher T. Lin, Chin-Hsing Annie Neural Regen Res Review Mechanisms regulating neurogenesis involve broad and complex processes that represent intriguing therapeutic targets in the field of regenerative medicine. One influential factor guiding neural stem cell proliferation and cellular differentiation during neurogenesis are epigenetic mechanisms. We present an overview of epigenetic mechanisms including chromatin structure and histone modifications; and discuss novel roles of two histone modifiers, Ezh2 and Suv4-20h1/Suv4-20h2 (collectively referred to as Suv4-20h), in neurodevelopment and neurogenesis. This review will focus on broadly reviewing epigenetic regulatory components, the roles of epigenetic components during neurogenesis, and potential applications in regenerative medicine. Wolters Kluwer - Medknow 2022-08-02 /pmc/articles/PMC9727419/ /pubmed/36018148 http://dx.doi.org/10.4103/1673-5374.350188 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Rhodes, Christopher T.
Lin, Chin-Hsing Annie
Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis
title Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis
title_full Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis
title_fullStr Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis
title_full_unstemmed Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis
title_short Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis
title_sort role of the histone methyltransferases ezh2 and suv4-20h1/suv4-20h2 in neurogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727419/
https://www.ncbi.nlm.nih.gov/pubmed/36018148
http://dx.doi.org/10.4103/1673-5374.350188
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