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Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis
Neurodegeneration affects a large number of cell types including neurons, astrocytes or oligodendrocytes, and neural stem cells. Neural stem cells can generate new neuronal populations through proliferation, migration, and differentiation. This neurogenic potential may be a relevant factor to fight...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727438/ https://www.ncbi.nlm.nih.gov/pubmed/36018154 http://dx.doi.org/10.4103/1673-5374.350189 |
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author | Romero, Alejandro Morales-García, José Ángel Ramos, Eva |
author_facet | Romero, Alejandro Morales-García, José Ángel Ramos, Eva |
author_sort | Romero, Alejandro |
collection | PubMed |
description | Neurodegeneration affects a large number of cell types including neurons, astrocytes or oligodendrocytes, and neural stem cells. Neural stem cells can generate new neuronal populations through proliferation, migration, and differentiation. This neurogenic potential may be a relevant factor to fight neurodegeneration and aging. In the last years, we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal neurogenesis. The lack of therapeutic strategies targeting neurogenesis led researchers to explore new molecules. Numerous preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in neurogenesis. We made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration, to summarize the current knowledge and highlight the therapeutic potential of melatonin. |
format | Online Article Text |
id | pubmed-9727438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-97274382022-12-08 Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis Romero, Alejandro Morales-García, José Ángel Ramos, Eva Neural Regen Res Review Neurodegeneration affects a large number of cell types including neurons, astrocytes or oligodendrocytes, and neural stem cells. Neural stem cells can generate new neuronal populations through proliferation, migration, and differentiation. This neurogenic potential may be a relevant factor to fight neurodegeneration and aging. In the last years, we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal neurogenesis. The lack of therapeutic strategies targeting neurogenesis led researchers to explore new molecules. Numerous preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in neurogenesis. We made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration, to summarize the current knowledge and highlight the therapeutic potential of melatonin. Wolters Kluwer - Medknow 2022-08-02 /pmc/articles/PMC9727438/ /pubmed/36018154 http://dx.doi.org/10.4103/1673-5374.350189 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Romero, Alejandro Morales-García, José Ángel Ramos, Eva Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis |
title | Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis |
title_full | Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis |
title_fullStr | Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis |
title_full_unstemmed | Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis |
title_short | Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis |
title_sort | melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727438/ https://www.ncbi.nlm.nih.gov/pubmed/36018154 http://dx.doi.org/10.4103/1673-5374.350189 |
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