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Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages

BACKGROUND: As the lymph-node metastasis rate and sites vary among pancreatic head carcinomas (PHCs) of different T stages, selective extended lymphadenectomy (ELD) performance may improve the prognosis of patients with PHC. AIM: To investigate the effect of ELD on the long-term prognosis of patient...

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Autores principales: Lyu, Shao-Cheng, Wang, Han-Xuan, Liu, Ze-Ping, Wang, Jing, Huang, Jin-Can, He, Qiang, Lang, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727567/
https://www.ncbi.nlm.nih.gov/pubmed/36504521
http://dx.doi.org/10.4240/wjgs.v14.i11.1204
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author Lyu, Shao-Cheng
Wang, Han-Xuan
Liu, Ze-Ping
Wang, Jing
Huang, Jin-Can
He, Qiang
Lang, Ren
author_facet Lyu, Shao-Cheng
Wang, Han-Xuan
Liu, Ze-Ping
Wang, Jing
Huang, Jin-Can
He, Qiang
Lang, Ren
author_sort Lyu, Shao-Cheng
collection PubMed
description BACKGROUND: As the lymph-node metastasis rate and sites vary among pancreatic head carcinomas (PHCs) of different T stages, selective extended lymphadenectomy (ELD) performance may improve the prognosis of patients with PHC. AIM: To investigate the effect of ELD on the long-term prognosis of patients with PHC of different T stages. METHODS: We analyzed data from 216 patients with PHC who underwent surgery at our hospital between January 2011 and December 2021. The patients were divided into extended and standard lymphadenectomy (SLD) groups according to extent of lymphadenectomy and into T1, T2, and T3 groups according to the 8(th) edition of the American Joint Committee on Cancer’s staging system. Perioperative data and prognoses were compared among groups. Risk factors associated with prognoses were identified through univariate and multivariate analyses. RESULTS: The 1-, 2- and 3-year overall survival (OS) rates in the extended and SLD groups were 69.0%, 39.5%, and 26.8% and 55.1%, 32.6%, and 22.1%, respectively (P = 0.073). The 1-, 2- and 3-year disease-free survival rates in the extended and SLD groups of patients with stage-T3 PHC were 50.3%, 25.1%, and 15.1% and 22.1%, 1.7%, and 0%, respectively (P = 0.025); the corresponding OS rates were 65.3%, 38.1%, and 21.8% and 36.1%, 7.5%, and 0%, respectively (P = 0.073). Multivariate analysis indicated that portal vein invasion and lymphadenectomy extent were risk factors for prognosis in patients with stage-T3 PHC. CONCLUSION: ELD may improve the prognosis of patients with stage-T3 PHC and may be of benefit if performed selectively.
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spelling pubmed-97275672022-12-08 Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages Lyu, Shao-Cheng Wang, Han-Xuan Liu, Ze-Ping Wang, Jing Huang, Jin-Can He, Qiang Lang, Ren World J Gastrointest Surg Retrospective Cohort Study BACKGROUND: As the lymph-node metastasis rate and sites vary among pancreatic head carcinomas (PHCs) of different T stages, selective extended lymphadenectomy (ELD) performance may improve the prognosis of patients with PHC. AIM: To investigate the effect of ELD on the long-term prognosis of patients with PHC of different T stages. METHODS: We analyzed data from 216 patients with PHC who underwent surgery at our hospital between January 2011 and December 2021. The patients were divided into extended and standard lymphadenectomy (SLD) groups according to extent of lymphadenectomy and into T1, T2, and T3 groups according to the 8(th) edition of the American Joint Committee on Cancer’s staging system. Perioperative data and prognoses were compared among groups. Risk factors associated with prognoses were identified through univariate and multivariate analyses. RESULTS: The 1-, 2- and 3-year overall survival (OS) rates in the extended and SLD groups were 69.0%, 39.5%, and 26.8% and 55.1%, 32.6%, and 22.1%, respectively (P = 0.073). The 1-, 2- and 3-year disease-free survival rates in the extended and SLD groups of patients with stage-T3 PHC were 50.3%, 25.1%, and 15.1% and 22.1%, 1.7%, and 0%, respectively (P = 0.025); the corresponding OS rates were 65.3%, 38.1%, and 21.8% and 36.1%, 7.5%, and 0%, respectively (P = 0.073). Multivariate analysis indicated that portal vein invasion and lymphadenectomy extent were risk factors for prognosis in patients with stage-T3 PHC. CONCLUSION: ELD may improve the prognosis of patients with stage-T3 PHC and may be of benefit if performed selectively. Baishideng Publishing Group Inc 2022-11-27 2022-11-27 /pmc/articles/PMC9727567/ /pubmed/36504521 http://dx.doi.org/10.4240/wjgs.v14.i11.1204 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Retrospective Cohort Study
Lyu, Shao-Cheng
Wang, Han-Xuan
Liu, Ze-Ping
Wang, Jing
Huang, Jin-Can
He, Qiang
Lang, Ren
Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages
title Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages
title_full Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages
title_fullStr Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages
title_full_unstemmed Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages
title_short Clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different T stages
title_sort clinical value of extended lymphadenectomy in radical surgery for pancreatic head carcinoma at different t stages
topic Retrospective Cohort Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727567/
https://www.ncbi.nlm.nih.gov/pubmed/36504521
http://dx.doi.org/10.4240/wjgs.v14.i11.1204
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