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Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum

BACKGROUND: Few studies compared the oncological and biological characteristics between ampullary carcinoma (AC) and cancer of the second portion of the duodenum (DC-II), although both tumors arise from anatomically close locations. AIM: To elucidate differences in clinicopathological characteristic...

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Autores principales: Nishio, Kohei, Kimura, Kenjiro, Murata, Akihiro, Ohira, Go, Shinkawa, Hiroji, Kodai, Shintaro, Amano, Ryosuke, Tanaka, Shogo, Shimizu, Sadatoshi, Takemura, Shigekazu, Kanazawa, Akishige, Kubo, Shoji, Ishizawa, Takeaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727577/
https://www.ncbi.nlm.nih.gov/pubmed/36504514
http://dx.doi.org/10.4240/wjgs.v14.i11.1219
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author Nishio, Kohei
Kimura, Kenjiro
Murata, Akihiro
Ohira, Go
Shinkawa, Hiroji
Kodai, Shintaro
Amano, Ryosuke
Tanaka, Shogo
Shimizu, Sadatoshi
Takemura, Shigekazu
Kanazawa, Akishige
Kubo, Shoji
Ishizawa, Takeaki
author_facet Nishio, Kohei
Kimura, Kenjiro
Murata, Akihiro
Ohira, Go
Shinkawa, Hiroji
Kodai, Shintaro
Amano, Ryosuke
Tanaka, Shogo
Shimizu, Sadatoshi
Takemura, Shigekazu
Kanazawa, Akishige
Kubo, Shoji
Ishizawa, Takeaki
author_sort Nishio, Kohei
collection PubMed
description BACKGROUND: Few studies compared the oncological and biological characteristics between ampullary carcinoma (AC) and cancer of the second portion of the duodenum (DC-II), although both tumors arise from anatomically close locations. AIM: To elucidate differences in clinicopathological characteristics, especially the patterns of lymph node metastasis (LNM), between AC and DC-II. METHODS: This was a retrospective cohort study of 80 patients with AC and 27 patients with DC-II who underwent pancreaticoduodenectomy between January 1998 and December 2018 in two institutions. Clinicopathological factors, LNM patterns, and prognosis were compared between the two groups. RESULTS: The patients with AC and DC-II did not exhibit significant differences in 5-year overall survival (66.0% and 67.1%, respectively) and 5-year relapse-free survival (63.5% and 62.2%, respectively). Compared to the patients with DC-II, the rate of preoperative biliary drainage was higher (P = 0.042) and the rates of digestive symptoms (P = 0.0158), ulcerative-type cancer (P < 0.0001), large tumor diameter (P < 0.0001), and advanced tumor stage (P = 0.0019) were lower in the patients with AC. The LNM rates were 27.5% and 40.7% in patients with AC and DC-II, respectively, without significant difference (P = 0.23). The rates of LNM to hepatic nodes (N-He) and pyloric nodes (N-Py) were significantly higher in patients with DC-II than in those with AC (metastasis to N-HE: 18.5% and 5% in patients with DC-II and AC, respectively; P = 0.0432; metastasis to N-Py: 11.1% and 0% in patients with DC-II and AC, respectively; P = 0.0186) CONCLUSION: Although there were no significant differences in the prognosis and recurrence rates between the two groups, metastases to N-He and N-Py were more frequent in patients with DC-II than in those with AC.
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spelling pubmed-97275772022-12-08 Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum Nishio, Kohei Kimura, Kenjiro Murata, Akihiro Ohira, Go Shinkawa, Hiroji Kodai, Shintaro Amano, Ryosuke Tanaka, Shogo Shimizu, Sadatoshi Takemura, Shigekazu Kanazawa, Akishige Kubo, Shoji Ishizawa, Takeaki World J Gastrointest Surg Retrospective Cohort Study BACKGROUND: Few studies compared the oncological and biological characteristics between ampullary carcinoma (AC) and cancer of the second portion of the duodenum (DC-II), although both tumors arise from anatomically close locations. AIM: To elucidate differences in clinicopathological characteristics, especially the patterns of lymph node metastasis (LNM), between AC and DC-II. METHODS: This was a retrospective cohort study of 80 patients with AC and 27 patients with DC-II who underwent pancreaticoduodenectomy between January 1998 and December 2018 in two institutions. Clinicopathological factors, LNM patterns, and prognosis were compared between the two groups. RESULTS: The patients with AC and DC-II did not exhibit significant differences in 5-year overall survival (66.0% and 67.1%, respectively) and 5-year relapse-free survival (63.5% and 62.2%, respectively). Compared to the patients with DC-II, the rate of preoperative biliary drainage was higher (P = 0.042) and the rates of digestive symptoms (P = 0.0158), ulcerative-type cancer (P < 0.0001), large tumor diameter (P < 0.0001), and advanced tumor stage (P = 0.0019) were lower in the patients with AC. The LNM rates were 27.5% and 40.7% in patients with AC and DC-II, respectively, without significant difference (P = 0.23). The rates of LNM to hepatic nodes (N-He) and pyloric nodes (N-Py) were significantly higher in patients with DC-II than in those with AC (metastasis to N-HE: 18.5% and 5% in patients with DC-II and AC, respectively; P = 0.0432; metastasis to N-Py: 11.1% and 0% in patients with DC-II and AC, respectively; P = 0.0186) CONCLUSION: Although there were no significant differences in the prognosis and recurrence rates between the two groups, metastases to N-He and N-Py were more frequent in patients with DC-II than in those with AC. Baishideng Publishing Group Inc 2022-11-27 2022-11-27 /pmc/articles/PMC9727577/ /pubmed/36504514 http://dx.doi.org/10.4240/wjgs.v14.i11.1219 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Retrospective Cohort Study
Nishio, Kohei
Kimura, Kenjiro
Murata, Akihiro
Ohira, Go
Shinkawa, Hiroji
Kodai, Shintaro
Amano, Ryosuke
Tanaka, Shogo
Shimizu, Sadatoshi
Takemura, Shigekazu
Kanazawa, Akishige
Kubo, Shoji
Ishizawa, Takeaki
Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum
title Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum
title_full Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum
title_fullStr Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum
title_full_unstemmed Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum
title_short Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum
title_sort comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum
topic Retrospective Cohort Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727577/
https://www.ncbi.nlm.nih.gov/pubmed/36504514
http://dx.doi.org/10.4240/wjgs.v14.i11.1219
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