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Identification of an E3 ligase that targets the catalytic subunit of RNA Polymerase I upon transcription stress

RNA Polymerase I (Pol I) synthesizes rRNA, which is the first and rate-limiting step in ribosome biogenesis. Factors governing the stability of the polymerase complex are not known. Previous studies characterizing Pol I inhibitor BMH-21 revealed a transcriptional stress-dependent pathway for degrada...

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Detalles Bibliográficos
Autores principales:	Pitts, Stephanie, Liu, Hester, Ibrahim, Adel, Garg, Amit, Felgueira, Catarina Mendes, Begum, Asma, Fan, Wenjun, Teh, Selina, Low, Jin-Yih, Ford, Brittany, Schneider, David A., Hay, Ronald, Laiho, Marikki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727647/ https://www.ncbi.nlm.nih.gov/pubmed/36372232 http://dx.doi.org/10.1016/j.jbc.2022.102690

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