Cargando…
Membrane fusion by Drosophila atlastin does not require GTP hydrolysis
Atlastin (ATL) GTPases undergo trans dimerization and a power strokelike crossover conformational rearrangement to drive endoplasmic reticulum membrane fusion. Fusion depends on GTP, but the role of nucleotide hydrolysis has remained controversial. For instance, nonhydrolyzable GTP analogs block fus...
Autores principales: | Crosby, Daniel, Lee, Tina H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727788/ https://www.ncbi.nlm.nih.gov/pubmed/36129776 http://dx.doi.org/10.1091/mbc.E22-05-0164 |
Ejemplares similares
-
GTP hydrolysis promotes disassembly of the atlastin crossover dimer during ER fusion
por: Winsor, James, et al.
Publicado: (2018) -
Membrane tethering by the atlastin GTPase depends on GTP hydrolysis but not on forming the cross-over configuration
por: Saini, Simran G., et al.
Publicado: (2014) -
Human atlastin-3 is a constitutive ER membrane fusion catalyst
por: Bryce, Samantha, et al.
Publicado: (2023) -
Reconstitution of human atlastin fusion activity reveals autoinhibition by the C terminus
por: Crosby, Daniel, et al.
Publicado: (2021) -
An intramolecular salt bridge drives the soluble domain of GTP-bound atlastin into the postfusion conformation
por: Morin-Leisk, Jeanne, et al.
Publicado: (2011)