Stress deprivation of tendon explants or Tpm3.1 inhibition in tendon cells reduces F-actin to promote a tendinosis-like phenotype

Actin is a central mediator between mechanical force and cellular phenotype. In tendons, it is speculated that mechanical stress deprivation regulates gene expression by reducing filamentous (F)-actin. However, the mechanisms regulating tenocyte F-actin remain unclear. Tropomyosins (Tpms) are master...

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Autores principales: Inguito, Kameron L., Schofield, Mandy M., Faghri, Arya D., Bloom, Ellen T., Heino, Marissa, West, Valerie C., Ebron, Karl Matthew M., Elliott, Dawn M., Parreno, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727789/
https://www.ncbi.nlm.nih.gov/pubmed/36129771
http://dx.doi.org/10.1091/mbc.E22-02-0067

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