Agent-based modeling predicts RAC1 is critical for ovarian cancer metastasis

Experimental and computational studies pinpoint rate-limiting step(s) in metastasis governed by Rac1. Using ovarian cancer cell and animal models, Rac1 expression was manipulated, and quantitative measurements of cell–cell and cell–substrate adhesion, cell invasion, mesothelial clearance, and perito...

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Detalles Bibliográficos
Autores principales: Rivera, Melanie, Toledo-Jacobo, Leslie, Romero, Elsa, Oprea, Tudor I., Moses, Melanie E., Hudson, Laurie G., Wandinger-Ness, Angela, Grimes, Martha M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727804/
https://www.ncbi.nlm.nih.gov/pubmed/36200848
http://dx.doi.org/10.1091/mbc.E21-11-0540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727804/
https://www.ncbi.nlm.nih.gov/pubmed/36200848
http://dx.doi.org/10.1091/mbc.E21-11-0540

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