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Agent-based modeling predicts RAC1 is critical for ovarian cancer metastasis
Experimental and computational studies pinpoint rate-limiting step(s) in metastasis governed by Rac1. Using ovarian cancer cell and animal models, Rac1 expression was manipulated, and quantitative measurements of cell–cell and cell–substrate adhesion, cell invasion, mesothelial clearance, and perito...
Autores principales: | Rivera, Melanie, Toledo-Jacobo, Leslie, Romero, Elsa, Oprea, Tudor I., Moses, Melanie E., Hudson, Laurie G., Wandinger-Ness, Angela, Grimes, Martha M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727804/ https://www.ncbi.nlm.nih.gov/pubmed/36200848 http://dx.doi.org/10.1091/mbc.E21-11-0540 |
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