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Coronavirus peplomer interaction

By virtue of their lack of motility, viruses rely entirely on their own temperature (Brownian motion) to position themselves properly for cell attachment. Spiked viruses use one or more spikes (called peplomers) to attach. The coronavirus uses adjacent peplomer pairs. These peplomers, identically ch...

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Autores principales: Pak, Myong Chol, Chakraborty, R., Kanso, M. A., Tontiwattanakul, K., Kim, Kwang-Il, Giacomin, A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728042/
https://www.ncbi.nlm.nih.gov/pubmed/36505011
http://dx.doi.org/10.1063/5.0120167
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author Pak, Myong Chol
Chakraborty, R.
Kanso, M. A.
Tontiwattanakul, K.
Kim, Kwang-Il
Giacomin, A. J.
author_facet Pak, Myong Chol
Chakraborty, R.
Kanso, M. A.
Tontiwattanakul, K.
Kim, Kwang-Il
Giacomin, A. J.
author_sort Pak, Myong Chol
collection PubMed
description By virtue of their lack of motility, viruses rely entirely on their own temperature (Brownian motion) to position themselves properly for cell attachment. Spiked viruses use one or more spikes (called peplomers) to attach. The coronavirus uses adjacent peplomer pairs. These peplomers, identically charged, repel one another over the surface of their convex capsids to form beautiful polyhedra. We identify the edges of these polyhedra with the most important peplomer hydrodynamic interactions. These convex capsids may or may not be spherical, and their peplomer population declines with infection time. These peplomers are short, equidimensional, and bulbous with triangular bulbs. In this short paper, we explore the interactions between nearby peplomer bulbs. By interactions, we mean the hydrodynamic interferences between the velocity profiles caused by the drag of the suspending fluid when the virus rotates. We find that these peplomer hydrodynamic interactions raise rotational diffusivity of the virus, and thus affect its ability to infect.
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spelling pubmed-97280422022-12-08 Coronavirus peplomer interaction Pak, Myong Chol Chakraborty, R. Kanso, M. A. Tontiwattanakul, K. Kim, Kwang-Il Giacomin, A. J. Phys Fluids (1994) ARTICLES By virtue of their lack of motility, viruses rely entirely on their own temperature (Brownian motion) to position themselves properly for cell attachment. Spiked viruses use one or more spikes (called peplomers) to attach. The coronavirus uses adjacent peplomer pairs. These peplomers, identically charged, repel one another over the surface of their convex capsids to form beautiful polyhedra. We identify the edges of these polyhedra with the most important peplomer hydrodynamic interactions. These convex capsids may or may not be spherical, and their peplomer population declines with infection time. These peplomers are short, equidimensional, and bulbous with triangular bulbs. In this short paper, we explore the interactions between nearby peplomer bulbs. By interactions, we mean the hydrodynamic interferences between the velocity profiles caused by the drag of the suspending fluid when the virus rotates. We find that these peplomer hydrodynamic interactions raise rotational diffusivity of the virus, and thus affect its ability to infect. AIP Publishing LLC 2022-11 2022-11-30 /pmc/articles/PMC9728042/ /pubmed/36505011 http://dx.doi.org/10.1063/5.0120167 Text en © 2022 Author(s). https://creativecommons.org/licenses/by/4.0/ All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle ARTICLES
Pak, Myong Chol
Chakraborty, R.
Kanso, M. A.
Tontiwattanakul, K.
Kim, Kwang-Il
Giacomin, A. J.
Coronavirus peplomer interaction
title Coronavirus peplomer interaction
title_full Coronavirus peplomer interaction
title_fullStr Coronavirus peplomer interaction
title_full_unstemmed Coronavirus peplomer interaction
title_short Coronavirus peplomer interaction
title_sort coronavirus peplomer interaction
topic ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728042/
https://www.ncbi.nlm.nih.gov/pubmed/36505011
http://dx.doi.org/10.1063/5.0120167
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