Cargando…
Coronavirus peplomer interaction
By virtue of their lack of motility, viruses rely entirely on their own temperature (Brownian motion) to position themselves properly for cell attachment. Spiked viruses use one or more spikes (called peplomers) to attach. The coronavirus uses adjacent peplomer pairs. These peplomers, identically ch...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728042/ https://www.ncbi.nlm.nih.gov/pubmed/36505011 http://dx.doi.org/10.1063/5.0120167 |
_version_ | 1784845160159379456 |
---|---|
author | Pak, Myong Chol Chakraborty, R. Kanso, M. A. Tontiwattanakul, K. Kim, Kwang-Il Giacomin, A. J. |
author_facet | Pak, Myong Chol Chakraborty, R. Kanso, M. A. Tontiwattanakul, K. Kim, Kwang-Il Giacomin, A. J. |
author_sort | Pak, Myong Chol |
collection | PubMed |
description | By virtue of their lack of motility, viruses rely entirely on their own temperature (Brownian motion) to position themselves properly for cell attachment. Spiked viruses use one or more spikes (called peplomers) to attach. The coronavirus uses adjacent peplomer pairs. These peplomers, identically charged, repel one another over the surface of their convex capsids to form beautiful polyhedra. We identify the edges of these polyhedra with the most important peplomer hydrodynamic interactions. These convex capsids may or may not be spherical, and their peplomer population declines with infection time. These peplomers are short, equidimensional, and bulbous with triangular bulbs. In this short paper, we explore the interactions between nearby peplomer bulbs. By interactions, we mean the hydrodynamic interferences between the velocity profiles caused by the drag of the suspending fluid when the virus rotates. We find that these peplomer hydrodynamic interactions raise rotational diffusivity of the virus, and thus affect its ability to infect. |
format | Online Article Text |
id | pubmed-9728042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-97280422022-12-08 Coronavirus peplomer interaction Pak, Myong Chol Chakraborty, R. Kanso, M. A. Tontiwattanakul, K. Kim, Kwang-Il Giacomin, A. J. Phys Fluids (1994) ARTICLES By virtue of their lack of motility, viruses rely entirely on their own temperature (Brownian motion) to position themselves properly for cell attachment. Spiked viruses use one or more spikes (called peplomers) to attach. The coronavirus uses adjacent peplomer pairs. These peplomers, identically charged, repel one another over the surface of their convex capsids to form beautiful polyhedra. We identify the edges of these polyhedra with the most important peplomer hydrodynamic interactions. These convex capsids may or may not be spherical, and their peplomer population declines with infection time. These peplomers are short, equidimensional, and bulbous with triangular bulbs. In this short paper, we explore the interactions between nearby peplomer bulbs. By interactions, we mean the hydrodynamic interferences between the velocity profiles caused by the drag of the suspending fluid when the virus rotates. We find that these peplomer hydrodynamic interactions raise rotational diffusivity of the virus, and thus affect its ability to infect. AIP Publishing LLC 2022-11 2022-11-30 /pmc/articles/PMC9728042/ /pubmed/36505011 http://dx.doi.org/10.1063/5.0120167 Text en © 2022 Author(s). https://creativecommons.org/licenses/by/4.0/ All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | ARTICLES Pak, Myong Chol Chakraborty, R. Kanso, M. A. Tontiwattanakul, K. Kim, Kwang-Il Giacomin, A. J. Coronavirus peplomer interaction |
title | Coronavirus peplomer interaction |
title_full | Coronavirus peplomer interaction |
title_fullStr | Coronavirus peplomer interaction |
title_full_unstemmed | Coronavirus peplomer interaction |
title_short | Coronavirus peplomer interaction |
title_sort | coronavirus peplomer interaction |
topic | ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728042/ https://www.ncbi.nlm.nih.gov/pubmed/36505011 http://dx.doi.org/10.1063/5.0120167 |
work_keys_str_mv | AT pakmyongchol coronaviruspeplomerinteraction AT chakrabortyr coronaviruspeplomerinteraction AT kansoma coronaviruspeplomerinteraction AT tontiwattanakulk coronaviruspeplomerinteraction AT kimkwangil coronaviruspeplomerinteraction AT giacominaj coronaviruspeplomerinteraction |