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Omega Rhodopsins: A Versatile Class of Microbial Rhodopsins

Microbial rhodopsins are a superfamily of photoactive membrane proteins with the covalently bound retinal cofactor. Isomerization of the retinal chromophore upon absorption of a photon triggers conformational changes of the protein to function as ion pumps or sensors. After the discovery of proteorh...

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Detalles Bibliográficos
Autores principales: Kwon, Soon-Kyeong, Jun, Sung-Hoon, Kim, Jihyun F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Microbiology and Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728251/
https://www.ncbi.nlm.nih.gov/pubmed/32482928
http://dx.doi.org/10.4014/jmb.1912.12010
Descripción
Sumario:Microbial rhodopsins are a superfamily of photoactive membrane proteins with the covalently bound retinal cofactor. Isomerization of the retinal chromophore upon absorption of a photon triggers conformational changes of the protein to function as ion pumps or sensors. After the discovery of proteorhodopsin in an uncultivated γ-proteobacterium, light-activated proton pumps have been widely detected among marine bacteria and, together with chlorophyll-based photosynthesis, are considered as an important axis responsible for primary production in the biosphere. Rhodopsins and related proteins show a high level of phylogenetic diversity; we focus on a specific class of bacterial rhodopsins containing the ‘3 omega motif.’ This motif forms a stack of three non-consecutive aromatic amino acids that correlates with the B–C loop orientation and is shared among the phylogenetically close ion pumps such as the NDQ motif-containing sodiumpumping rhodopsin, the NTQ motif-containing chloride-pumping rhodopsin, and some protonpumping rhodopsins including xanthorhodopsin. Here, we reviewed the recent research progress on these ‘omega rhodopsins,’ and speculated on their evolutionary origin of functional diversity.