Cargando…

Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging

Ultraviolet (UV) is one of the major factors harmful to skin health. Irradiation with ultraviolet accelerates the decline of skin function, causing the skin to have deep wrinkles, dryness, decreased procollagen production, and degradation of collagen. Novel materials are needed to prevent the aging...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Eun Hee, Yang, Hee, Kim, Jong-Eun, Lee, Ki Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Microbiology and Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728390/
https://www.ncbi.nlm.nih.gov/pubmed/32522955
http://dx.doi.org/10.4014/jmb.2003.03064
_version_ 1784845241972424704
author Jeong, Eun Hee
Yang, Hee
Kim, Jong-Eun
Lee, Ki Won
author_facet Jeong, Eun Hee
Yang, Hee
Kim, Jong-Eun
Lee, Ki Won
author_sort Jeong, Eun Hee
collection PubMed
description Ultraviolet (UV) is one of the major factors harmful to skin health. Irradiation with ultraviolet accelerates the decline of skin function, causing the skin to have deep wrinkles, dryness, decreased procollagen production, and degradation of collagen. Novel materials are needed to prevent the aging of the skin by blocking the effects of UV. Safflower seed oil (Charthamus tinctorius L., SSO) contains significantly high levels of unsaturated fatty acids and phytochemicals. SSO has been traditionally used in China, Japan, and Korea to improve skin and hair. Our objective in this study was to determine the effect of SSO and its active compound acacetin on UVB-induced skin photoaging in HaCaT cells and human dermal fibroblasts (HDF). SSO inhibited UVB-induced matrix metalloproteinase-1 (MMP-1) at both protein and mRNA levels in HaCaT cells and HDF. MMP-1 is known to play important roles in collagen degradation and wrinkle formation. Acacetin, a type of flavonoid, is present in SSO. Similar to SSO, acacetin also inhibited UVB-induced MMP-1 protein and mRNA levels in HaCaT cells and HDF. MMP-1 mRNA is primarily regulated by the mitogen-activated kinase (MAPK) signaling pathway. Acacetin regulated the phosphorylation of JNK1/2 and c-jun, but did not inhibit the phosphorylation of ERK1/2, p38 and AKT. Taken together, these results indicate that SSO and its active compound acacetin can prevent UVB-induced MMP-1 expression, which leads to skin photoaging, and may therefore have therapeutic potential as an anti-wrinkle agent to improve skin health.
format Online
Article
Text
id pubmed-9728390
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Korean Society for Microbiology and Biotechnology
record_format MEDLINE/PubMed
spelling pubmed-97283902022-12-13 Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging Jeong, Eun Hee Yang, Hee Kim, Jong-Eun Lee, Ki Won J Microbiol Biotechnol Research article Ultraviolet (UV) is one of the major factors harmful to skin health. Irradiation with ultraviolet accelerates the decline of skin function, causing the skin to have deep wrinkles, dryness, decreased procollagen production, and degradation of collagen. Novel materials are needed to prevent the aging of the skin by blocking the effects of UV. Safflower seed oil (Charthamus tinctorius L., SSO) contains significantly high levels of unsaturated fatty acids and phytochemicals. SSO has been traditionally used in China, Japan, and Korea to improve skin and hair. Our objective in this study was to determine the effect of SSO and its active compound acacetin on UVB-induced skin photoaging in HaCaT cells and human dermal fibroblasts (HDF). SSO inhibited UVB-induced matrix metalloproteinase-1 (MMP-1) at both protein and mRNA levels in HaCaT cells and HDF. MMP-1 is known to play important roles in collagen degradation and wrinkle formation. Acacetin, a type of flavonoid, is present in SSO. Similar to SSO, acacetin also inhibited UVB-induced MMP-1 protein and mRNA levels in HaCaT cells and HDF. MMP-1 mRNA is primarily regulated by the mitogen-activated kinase (MAPK) signaling pathway. Acacetin regulated the phosphorylation of JNK1/2 and c-jun, but did not inhibit the phosphorylation of ERK1/2, p38 and AKT. Taken together, these results indicate that SSO and its active compound acacetin can prevent UVB-induced MMP-1 expression, which leads to skin photoaging, and may therefore have therapeutic potential as an anti-wrinkle agent to improve skin health. Korean Society for Microbiology and Biotechnology 2020-10-28 2020-06-10 /pmc/articles/PMC9728390/ /pubmed/32522955 http://dx.doi.org/10.4014/jmb.2003.03064 Text en Copyright©2020 by The Korean Society for Microbiology and Biotechnology https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research article
Jeong, Eun Hee
Yang, Hee
Kim, Jong-Eun
Lee, Ki Won
Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
title Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
title_full Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
title_fullStr Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
title_full_unstemmed Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
title_short Safflower Seed Oil and Its Active Compound Acacetin Inhibit UVB-Induced Skin Photoaging
title_sort safflower seed oil and its active compound acacetin inhibit uvb-induced skin photoaging
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728390/
https://www.ncbi.nlm.nih.gov/pubmed/32522955
http://dx.doi.org/10.4014/jmb.2003.03064
work_keys_str_mv AT jeongeunhee safflowerseedoilanditsactivecompoundacacetininhibituvbinducedskinphotoaging
AT yanghee safflowerseedoilanditsactivecompoundacacetininhibituvbinducedskinphotoaging
AT kimjongeun safflowerseedoilanditsactivecompoundacacetininhibituvbinducedskinphotoaging
AT leekiwon safflowerseedoilanditsactivecompoundacacetininhibituvbinducedskinphotoaging