Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally, and the WHO has declared this outbreak a pandemic. Vaccines are an effective way to prevent the rapid spread of COVID-19. Furthermore, the immune response...

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Detalles Bibliográficos
Autores principales: Kim, Kyun-Do, Hwang, Insu, Ku†, Keun Bon, Lee, Sumin, Kim, Seong-Jun, Kim, Chonsaeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Microbiology and Biotechnology 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728398/
https://www.ncbi.nlm.nih.gov/pubmed/32627758
http://dx.doi.org/10.4014/jmb.2006.06006
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author Kim, Kyun-Do
Hwang, Insu
Ku†, Keun Bon
Lee, Sumin
Kim, Seong-Jun
Kim, Chonsaeng
author_facet Kim, Kyun-Do
Hwang, Insu
Ku†, Keun Bon
Lee, Sumin
Kim, Seong-Jun
Kim, Chonsaeng
author_sort Kim, Kyun-Do
collection PubMed
description The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally, and the WHO has declared this outbreak a pandemic. Vaccines are an effective way to prevent the rapid spread of COVID-19. Furthermore, the immune response against SARS-CoV-2 infection needs to be understood for the development of an efficient and safe vaccine. Here, we review the current understanding of vaccine targets and the status of vaccine development for COVID-19. We also describe host immune responses to highly pathogenic human coronaviruses in terms of innate and adaptive immunities.
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spelling pubmed-97283982022-12-13 Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses Kim, Kyun-Do Hwang, Insu Ku†, Keun Bon Lee, Sumin Kim, Seong-Jun Kim, Chonsaeng J Microbiol Biotechnol Review The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally, and the WHO has declared this outbreak a pandemic. Vaccines are an effective way to prevent the rapid spread of COVID-19. Furthermore, the immune response against SARS-CoV-2 infection needs to be understood for the development of an efficient and safe vaccine. Here, we review the current understanding of vaccine targets and the status of vaccine development for COVID-19. We also describe host immune responses to highly pathogenic human coronaviruses in terms of innate and adaptive immunities. The Korean Society for Microbiology and Biotechnology 2020-08-28 2020-06-16 /pmc/articles/PMC9728398/ /pubmed/32627758 http://dx.doi.org/10.4014/jmb.2006.06006 Text en Copyright © 2020 The Korean Society for Microbiology and Biotechnology https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kim, Kyun-Do
Hwang, Insu
Ku†, Keun Bon
Lee, Sumin
Kim, Seong-Jun
Kim, Chonsaeng
Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses
title Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses
title_full Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses
title_fullStr Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses
title_full_unstemmed Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses
title_short Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses
title_sort progress and challenges in the development of covid-19 vaccines and current understanding of sars-cov-2- specific immune responses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728398/
https://www.ncbi.nlm.nih.gov/pubmed/32627758
http://dx.doi.org/10.4014/jmb.2006.06006
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