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Substrate Affinity Versus Catalytic Efficiency: Ancestral Sequence Reconstruction of tRNA Nucleotidyltransferases Solves an Enzyme Puzzle

In tRNA maturation, CCA-addition by tRNA nucleotidyltransferase is a unique and highly accurate reaction. While the mechanism of nucleotide selection and polymerization is well understood, it remains a mystery why bacterial and eukaryotic enzymes exhibit an unexpected and surprisingly low tRNA subst...

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Detalles Bibliográficos
Autores principales:	Hager, Martina, Pöhler, Marie-Theres, Reinhardt, Franziska, Wellner, Karolin, Hübner, Jessica, Betat, Heike, Prohaska, Sonja, Mörl, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728577/ https://www.ncbi.nlm.nih.gov/pubmed/36409584 http://dx.doi.org/10.1093/molbev/msac250

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