Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care

We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-r...

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Autores principales: Srinivasan, Krishnamachari, Salazar, Luke Joshua, Heylen, Elsa, Ekstrand, Maria L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728592/
https://www.ncbi.nlm.nih.gov/pubmed/36483766
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author Srinivasan, Krishnamachari
Salazar, Luke Joshua
Heylen, Elsa
Ekstrand, Maria L.
author_facet Srinivasan, Krishnamachari
Salazar, Luke Joshua
Heylen, Elsa
Ekstrand, Maria L.
author_sort Srinivasan, Krishnamachari
collection PubMed
description We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (P = 0.67).
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spelling pubmed-97285922022-12-07 Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care Srinivasan, Krishnamachari Salazar, Luke Joshua Heylen, Elsa Ekstrand, Maria L. Int J Noncommun Dis Article We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (P = 0.67). 2022 2022-07-22 /pmc/articles/PMC9728592/ /pubmed/36483766 Text en https://creativecommons.org/licenses/by/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Article
Srinivasan, Krishnamachari
Salazar, Luke Joshua
Heylen, Elsa
Ekstrand, Maria L.
Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care
title Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care
title_full Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care
title_fullStr Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care
title_full_unstemmed Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care
title_short Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care
title_sort elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728592/
https://www.ncbi.nlm.nih.gov/pubmed/36483766
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AT heylenelsa elevatedhomocysteineanddepressionoutcomesinpatientswithcomorbidmedicalconditionsinruralprimarycare
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