A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia

PspA and pneumolysin are two important vaccine candidates, able to elicit protection in different models of pneumococcal infection. The high immunogenic potential of PspA, combined with a possible adjuvant effect of pneumolysin derivatives (due to their ability to interact with TLR-4) could greatly...

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Detalles Bibliográficos
Autores principales: dos Santos, Tanila Wood, Gonçalves, Pedro Almeida, Rodriguez, Dunia, Pereira, José Aires, Martinez, Carlos Augusto Real, Leite, Luciana C. C., Ferraz, Lucio F. C., Converso, Thiago Rojas, Darrieux, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728834/
https://www.ncbi.nlm.nih.gov/pubmed/36477013
http://dx.doi.org/10.1371/journal.pone.0277304

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