Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis B virus (HBV) infection, we performed a focused screen of epigenetic modifiers to identify potential inhibitors of r...

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Detalles Bibliográficos
Autores principales: Gilmore, Sarah A., Tam, Danny, Cheung, Tara L., Snyder, Chelsea, Farand, Julie, Dick, Ryan, Matles, Mike, Feng, Joy Y., Ramirez, Ricardo, Li, Li, Yu, Helen, Xu, Yili, Barnes, Dwight, Czerwieniec, Gregg, Brendza, Katherine M., Appleby, Todd C., Birkus, Gabriel, Willkom, Madeleine, Kobayashi, Tetsuya, Paoli, Eric, Labelle, Marc, Boesen, Thomas, Tay, Chin H., Delaney, William E., Notte, Gregory T., Schmitz, Uli, Feierbach, Becket
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728921/
https://www.ncbi.nlm.nih.gov/pubmed/36477212
http://dx.doi.org/10.1371/journal.pone.0271145

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