Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair

BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription and genome stability. Dysregulation of BRD4 is frequently observed in various human cancers. However, the molecular details of BRD4 regulation remain largely unknown. Here, we report that PRMT2- and PRMT4-med...

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Detalles Bibliográficos
Autores principales: Liu, Liu, Lin, Baicheng, Yin, Shasha, Ball, Lauren E., Delaney, Joe R., Long, David T., Gan, Wenjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728970/
https://www.ncbi.nlm.nih.gov/pubmed/36475791
http://dx.doi.org/10.1126/sciadv.add8928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728970/
https://www.ncbi.nlm.nih.gov/pubmed/36475791
http://dx.doi.org/10.1126/sciadv.add8928

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