Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response

The majority of lncRNAs’ roles in tumor immunology remain elusive. This project performed a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human CD8(+) T cells. We identified 16 lncRNAs potentially regulating tumor immune response. Further integrative analysis using tu...

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Detalles Bibliográficos
Autores principales: Wang, Yifei, Zhao, Yueshan, Guo, Weiwei, Yadav, Ghanshyam Singh, Bhaskarla, Chetana, Wang, Zehua, Wang, Xiaofei, Li, Sihan, Wang, Yue, Chen, Yuang, Pattarayan, Dhamotharan, Xie, Wen, Li, Song, Lu, Binfeng, Kammula, Udai S., Zhang, Min, Yang, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728976/
https://www.ncbi.nlm.nih.gov/pubmed/36475797
http://dx.doi.org/10.1126/sciadv.add0005

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