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Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

Determining the functional role of thousands of genetic sequence variants (mutations) associated with genetic diseases is a major challenge. Here we present clustered regularly interspaced short palindromic repeat (CRISPR)-Select(TIME), CRISPR-Select(SPACE) and CRISPR-Select(STATE), a set of flexibl...

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Detalles Bibliográficos
Autores principales: Niu, Yiyuan, Ferreira Azevedo, Catarina A., Li, Xin, Kamali, Elahe, Haagen Nielsen, Ole, Storgaard Sørensen, Claus, Frödin, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729100/
https://www.ncbi.nlm.nih.gov/pubmed/36471068
http://dx.doi.org/10.1038/s41588-022-01224-7