Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats in mammalian genomes. To what extent this entails direct inhibition of transcription factor (TF) binding versus indirect inhibition via recruitment of methyl-CpG-binding domain (MBD) proteins is unclear. Here...

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Detalles Bibliográficos
Autores principales: Kaluscha, Sebastian, Domcke, Silvia, Wirbelauer, Christiane, Stadler, Michael B., Durdu, Sevi, Burger, Lukas, Schübeler, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729108/
https://www.ncbi.nlm.nih.gov/pubmed/36471082
http://dx.doi.org/10.1038/s41588-022-01241-6

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