Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion

Cancer genetics has uncovered many tumor-suppressor and oncogenic pathways, but few alterations have revealed mechanisms involved in tumor spreading. Here, we examined the role of the third most significant chromosomal deletion in human melanoma that inactivates the adherens junction gene NECTIN1 in...

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Detalles Bibliográficos
Autores principales: Ablain, Julien, Al Mahi, Amira, Rothschild, Harriet, Prasad, Meera, Aires, Sophie, Yang, Song, Dokukin, Maxim E., Xu, Shuyun, Dang, Michelle, Sokolov, Igor, Lian, Christine G., Zon, Leonard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729115/
https://www.ncbi.nlm.nih.gov/pubmed/36229674
http://dx.doi.org/10.1038/s41588-022-01191-z

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