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Heterogeneous graph construction and HinSAGE learning from electronic medical records

Graph representation learning is a method for introducing how to effectively construct and learn patient embeddings using electronic medical records. Adapting the integration will support and advance the previous methods to predict the prognosis of patients in network models. This study aims to addr...

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Autores principales: Cho, Ha Na, Ahn, Imjin, Gwon, Hansle, Kang, Hee Jun, Kim, Yunha, Seo, Hyeram, Choi, Heejung, Kim, Minkyoung, Han, Jiye, Kee, Gaeun, Jun, Tae Joon, Kim, Young-Hak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729175/
https://www.ncbi.nlm.nih.gov/pubmed/36477457
http://dx.doi.org/10.1038/s41598-022-25693-2
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author Cho, Ha Na
Ahn, Imjin
Gwon, Hansle
Kang, Hee Jun
Kim, Yunha
Seo, Hyeram
Choi, Heejung
Kim, Minkyoung
Han, Jiye
Kee, Gaeun
Jun, Tae Joon
Kim, Young-Hak
author_facet Cho, Ha Na
Ahn, Imjin
Gwon, Hansle
Kang, Hee Jun
Kim, Yunha
Seo, Hyeram
Choi, Heejung
Kim, Minkyoung
Han, Jiye
Kee, Gaeun
Jun, Tae Joon
Kim, Young-Hak
author_sort Cho, Ha Na
collection PubMed
description Graph representation learning is a method for introducing how to effectively construct and learn patient embeddings using electronic medical records. Adapting the integration will support and advance the previous methods to predict the prognosis of patients in network models. This study aims to address the challenge of implementing a complex and highly heterogeneous dataset, including the following: (1) demonstrating how to build a multi-attributed and multi-relational graph model (2) and applying a downstream disease prediction task of a patient’s prognosis using the HinSAGE algorithm. We present a bipartite graph schema and a graph database construction in detail. The first constructed graph database illustrates a query of a predictive network that provides analytical insights using a graph representation of a patient’s journey. Moreover, we demonstrate an alternative bipartite model where we apply the model to the HinSAGE to perform the link prediction task for predicting the event occurrence. Consequently, the performance evaluation indicated that our heterogeneous graph model was successfully predicted as a baseline model. Overall, our graph database successfully demonstrated efficient real-time query performance and showed HinSAGE implementation to predict cardiovascular disease event outcomes on supervised link prediction learning.
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spelling pubmed-97291752022-12-09 Heterogeneous graph construction and HinSAGE learning from electronic medical records Cho, Ha Na Ahn, Imjin Gwon, Hansle Kang, Hee Jun Kim, Yunha Seo, Hyeram Choi, Heejung Kim, Minkyoung Han, Jiye Kee, Gaeun Jun, Tae Joon Kim, Young-Hak Sci Rep Article Graph representation learning is a method for introducing how to effectively construct and learn patient embeddings using electronic medical records. Adapting the integration will support and advance the previous methods to predict the prognosis of patients in network models. This study aims to address the challenge of implementing a complex and highly heterogeneous dataset, including the following: (1) demonstrating how to build a multi-attributed and multi-relational graph model (2) and applying a downstream disease prediction task of a patient’s prognosis using the HinSAGE algorithm. We present a bipartite graph schema and a graph database construction in detail. The first constructed graph database illustrates a query of a predictive network that provides analytical insights using a graph representation of a patient’s journey. Moreover, we demonstrate an alternative bipartite model where we apply the model to the HinSAGE to perform the link prediction task for predicting the event occurrence. Consequently, the performance evaluation indicated that our heterogeneous graph model was successfully predicted as a baseline model. Overall, our graph database successfully demonstrated efficient real-time query performance and showed HinSAGE implementation to predict cardiovascular disease event outcomes on supervised link prediction learning. Nature Publishing Group UK 2022-12-07 /pmc/articles/PMC9729175/ /pubmed/36477457 http://dx.doi.org/10.1038/s41598-022-25693-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cho, Ha Na
Ahn, Imjin
Gwon, Hansle
Kang, Hee Jun
Kim, Yunha
Seo, Hyeram
Choi, Heejung
Kim, Minkyoung
Han, Jiye
Kee, Gaeun
Jun, Tae Joon
Kim, Young-Hak
Heterogeneous graph construction and HinSAGE learning from electronic medical records
title Heterogeneous graph construction and HinSAGE learning from electronic medical records
title_full Heterogeneous graph construction and HinSAGE learning from electronic medical records
title_fullStr Heterogeneous graph construction and HinSAGE learning from electronic medical records
title_full_unstemmed Heterogeneous graph construction and HinSAGE learning from electronic medical records
title_short Heterogeneous graph construction and HinSAGE learning from electronic medical records
title_sort heterogeneous graph construction and hinsage learning from electronic medical records
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729175/
https://www.ncbi.nlm.nih.gov/pubmed/36477457
http://dx.doi.org/10.1038/s41598-022-25693-2
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