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Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases

High-dimensional omics datasets provide valuable resources to determine the causal role of molecular traits in mediating the path from genotype to phenotype. Making use of molecular quantitative trait loci (QTL) and genome-wide association study (GWAS) summary statistics, we propose a multivariable...

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Detalles Bibliográficos
Autores principales:	Sadler, Marie C., Auwerx, Chiara, Lepik, Kaido, Porcu, Eleonora, Kutalik, Zoltán
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729239/ https://www.ncbi.nlm.nih.gov/pubmed/36477627 http://dx.doi.org/10.1038/s41467-022-35196-3

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