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Functions and clinical significance of circular RNAs in acute myeloid leukemia

Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our understanding of the molecular functions of c...

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Autores principales: Zhou, Min, Gao, Xianling, Zheng, Xin, Luo, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729264/
https://www.ncbi.nlm.nih.gov/pubmed/36506538
http://dx.doi.org/10.3389/fphar.2022.1010579
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author Zhou, Min
Gao, Xianling
Zheng, Xin
Luo, Jing
author_facet Zhou, Min
Gao, Xianling
Zheng, Xin
Luo, Jing
author_sort Zhou, Min
collection PubMed
description Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our understanding of the molecular functions of circRNAs in sponging microRNAs, modulating transcription, regulating RNA-binding proteins, as well as encoding proteins have been made very recently. Dysregulated circRNAs are associated with human diseases such as acute myeloid leukemia (AML). In this review, we focus on the recently described mechanisms, role and clinical significance of circRNAs in AML. Although great progress of circRNAs in AML has been achieved, substantial efforts are still required to explore whether circRNAs exert their biological function by other mechanisms such as regulation of gene transcription or serving as translation template in AML. It is also urgent that researchers study the machineries regulating circRNAs fate, the downstream effectors of circRNAs modulatory networks, and the clinical application of circRNAs in AML.
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spelling pubmed-97292642022-12-09 Functions and clinical significance of circular RNAs in acute myeloid leukemia Zhou, Min Gao, Xianling Zheng, Xin Luo, Jing Front Pharmacol Pharmacology Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNA molecules. Four types of circRNAs have been reported in animal cells, and they have typical characteristics in their biogenesis, nuclear export and degradation. Advances in our understanding of the molecular functions of circRNAs in sponging microRNAs, modulating transcription, regulating RNA-binding proteins, as well as encoding proteins have been made very recently. Dysregulated circRNAs are associated with human diseases such as acute myeloid leukemia (AML). In this review, we focus on the recently described mechanisms, role and clinical significance of circRNAs in AML. Although great progress of circRNAs in AML has been achieved, substantial efforts are still required to explore whether circRNAs exert their biological function by other mechanisms such as regulation of gene transcription or serving as translation template in AML. It is also urgent that researchers study the machineries regulating circRNAs fate, the downstream effectors of circRNAs modulatory networks, and the clinical application of circRNAs in AML. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729264/ /pubmed/36506538 http://dx.doi.org/10.3389/fphar.2022.1010579 Text en Copyright © 2022 Zhou, Gao, Zheng and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhou, Min
Gao, Xianling
Zheng, Xin
Luo, Jing
Functions and clinical significance of circular RNAs in acute myeloid leukemia
title Functions and clinical significance of circular RNAs in acute myeloid leukemia
title_full Functions and clinical significance of circular RNAs in acute myeloid leukemia
title_fullStr Functions and clinical significance of circular RNAs in acute myeloid leukemia
title_full_unstemmed Functions and clinical significance of circular RNAs in acute myeloid leukemia
title_short Functions and clinical significance of circular RNAs in acute myeloid leukemia
title_sort functions and clinical significance of circular rnas in acute myeloid leukemia
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729264/
https://www.ncbi.nlm.nih.gov/pubmed/36506538
http://dx.doi.org/10.3389/fphar.2022.1010579
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