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Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria

Data recently reported by our group indicate that stimulation with a pool of immunogens capable of eliciting type 2 immune responses can restore the cognitive and behavioral dysfunctions recorded after a single episode of non-severe rodent malaria caused by Plasmodium berghei ANKA. Here we explored...

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Autores principales: Rosa-Gonçalves, Pamela, de Sousa, Luciana Pereira, Maia, Aline Barbosa, Ribeiro-Gomes, Flávia Lima, Gress, Caroline Cristhiani Tavares de Lima, Werneck, Guilherme Loureiro, Souza, Diogo Onofre, Almeida, Roberto Farina, Daniel-Ribeiro, Cláudio Tadeu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729266/
https://www.ncbi.nlm.nih.gov/pubmed/36505414
http://dx.doi.org/10.3389/fimmu.2022.1021211
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author Rosa-Gonçalves, Pamela
de Sousa, Luciana Pereira
Maia, Aline Barbosa
Ribeiro-Gomes, Flávia Lima
Gress, Caroline Cristhiani Tavares de Lima
Werneck, Guilherme Loureiro
Souza, Diogo Onofre
Almeida, Roberto Farina
Daniel-Ribeiro, Cláudio Tadeu
author_facet Rosa-Gonçalves, Pamela
de Sousa, Luciana Pereira
Maia, Aline Barbosa
Ribeiro-Gomes, Flávia Lima
Gress, Caroline Cristhiani Tavares de Lima
Werneck, Guilherme Loureiro
Souza, Diogo Onofre
Almeida, Roberto Farina
Daniel-Ribeiro, Cláudio Tadeu
author_sort Rosa-Gonçalves, Pamela
collection PubMed
description Data recently reported by our group indicate that stimulation with a pool of immunogens capable of eliciting type 2 immune responses can restore the cognitive and behavioral dysfunctions recorded after a single episode of non-severe rodent malaria caused by Plasmodium berghei ANKA. Here we explored the hypothesis that isolated immunization with one of the type 2 immune response-inducing immunogens, the human diphtheria-tetanus (dT) vaccine, may revert damages associated with malaria. To investigate this possibility, we studied the dynamics of cognitive deficits and anxiety-like phenotype following non-severe experimental malaria and evaluated the effects of immunization with both dT and of a pool of type 2 immune stimuli in reversing these impairments. Locomotor activity and long-term memory deficits were assessed through the open field test (OFT) and novel object recognition task (NORT), while the anxiety-like phenotype was assessed by OFT and light/dark task (LDT). Our results indicate that poor performance in cognitive-behavioral tests can be detected as early as the 12(th) day after the end of antimalarial treatment with chloroquine and may persist for up to 155 days post infection. The single immunization strategy with the human dT vaccine showed promise in reversal of long-term memory deficits in NORT, and anxiety-like behavior in OFT and LDT.
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spelling pubmed-97292662022-12-09 Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria Rosa-Gonçalves, Pamela de Sousa, Luciana Pereira Maia, Aline Barbosa Ribeiro-Gomes, Flávia Lima Gress, Caroline Cristhiani Tavares de Lima Werneck, Guilherme Loureiro Souza, Diogo Onofre Almeida, Roberto Farina Daniel-Ribeiro, Cláudio Tadeu Front Immunol Immunology Data recently reported by our group indicate that stimulation with a pool of immunogens capable of eliciting type 2 immune responses can restore the cognitive and behavioral dysfunctions recorded after a single episode of non-severe rodent malaria caused by Plasmodium berghei ANKA. Here we explored the hypothesis that isolated immunization with one of the type 2 immune response-inducing immunogens, the human diphtheria-tetanus (dT) vaccine, may revert damages associated with malaria. To investigate this possibility, we studied the dynamics of cognitive deficits and anxiety-like phenotype following non-severe experimental malaria and evaluated the effects of immunization with both dT and of a pool of type 2 immune stimuli in reversing these impairments. Locomotor activity and long-term memory deficits were assessed through the open field test (OFT) and novel object recognition task (NORT), while the anxiety-like phenotype was assessed by OFT and light/dark task (LDT). Our results indicate that poor performance in cognitive-behavioral tests can be detected as early as the 12(th) day after the end of antimalarial treatment with chloroquine and may persist for up to 155 days post infection. The single immunization strategy with the human dT vaccine showed promise in reversal of long-term memory deficits in NORT, and anxiety-like behavior in OFT and LDT. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729266/ /pubmed/36505414 http://dx.doi.org/10.3389/fimmu.2022.1021211 Text en Copyright © 2022 Rosa-Gonçalves, de Sousa, Maia, Ribeiro-Gomes, Gress, Werneck, Souza, Almeida and Daniel-Ribeiro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Rosa-Gonçalves, Pamela
de Sousa, Luciana Pereira
Maia, Aline Barbosa
Ribeiro-Gomes, Flávia Lima
Gress, Caroline Cristhiani Tavares de Lima
Werneck, Guilherme Loureiro
Souza, Diogo Onofre
Almeida, Roberto Farina
Daniel-Ribeiro, Cláudio Tadeu
Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria
title Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria
title_full Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria
title_fullStr Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria
title_full_unstemmed Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria
title_short Dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria
title_sort dynamics and immunomodulation of cognitive deficits and behavioral changes in non-severe experimental malaria
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729266/
https://www.ncbi.nlm.nih.gov/pubmed/36505414
http://dx.doi.org/10.3389/fimmu.2022.1021211
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