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Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond

Gastrointestinal (GI) cancers occur in the alimentary tract and accessory organs. They exert a global burden with high morbidity and mortality. Inside the tumor microenvironment, dendritic cells (DCs) are the most efficient antigen-presenting cells and are necessary for adaptive immune responses suc...

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Autores principales: Wang, Yinuo, Yang, Ting, Liang, Huan, Deng, Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729272/
https://www.ncbi.nlm.nih.gov/pubmed/36505406
http://dx.doi.org/10.3389/fimmu.2022.1007823
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author Wang, Yinuo
Yang, Ting
Liang, Huan
Deng, Mi
author_facet Wang, Yinuo
Yang, Ting
Liang, Huan
Deng, Mi
author_sort Wang, Yinuo
collection PubMed
description Gastrointestinal (GI) cancers occur in the alimentary tract and accessory organs. They exert a global burden with high morbidity and mortality. Inside the tumor microenvironment, dendritic cells (DCs) are the most efficient antigen-presenting cells and are necessary for adaptive immune responses such as T and B-cell maturation. However, the subsets of DCs revealed before were mostly based on flow cytometry and bulk sequencing. With the development of single-cell RNA sequencing (scRNA-seq), the tumor and microenvironment heterogeneity of GI cancer has been illustrated. In this review, we summarize the classification and development trajectory of dendritic cells at the single-cell level in GI cancer. Additionally, we focused on the interaction of DCs with T cells and their effect on the response to immunotherapy. Specifically, we focused on the newly identified tumor-infiltrating dendritic cells and discuss their potential function in antitumor immunity.
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spelling pubmed-97292722022-12-09 Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond Wang, Yinuo Yang, Ting Liang, Huan Deng, Mi Front Immunol Immunology Gastrointestinal (GI) cancers occur in the alimentary tract and accessory organs. They exert a global burden with high morbidity and mortality. Inside the tumor microenvironment, dendritic cells (DCs) are the most efficient antigen-presenting cells and are necessary for adaptive immune responses such as T and B-cell maturation. However, the subsets of DCs revealed before were mostly based on flow cytometry and bulk sequencing. With the development of single-cell RNA sequencing (scRNA-seq), the tumor and microenvironment heterogeneity of GI cancer has been illustrated. In this review, we summarize the classification and development trajectory of dendritic cells at the single-cell level in GI cancer. Additionally, we focused on the interaction of DCs with T cells and their effect on the response to immunotherapy. Specifically, we focused on the newly identified tumor-infiltrating dendritic cells and discuss their potential function in antitumor immunity. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729272/ /pubmed/36505406 http://dx.doi.org/10.3389/fimmu.2022.1007823 Text en Copyright © 2022 Wang, Yang, Liang and Deng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Yinuo
Yang, Ting
Liang, Huan
Deng, Mi
Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond
title Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond
title_full Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond
title_fullStr Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond
title_full_unstemmed Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond
title_short Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond
title_sort cell atlas of the immune microenvironment in gastrointestinal cancers: dendritic cells and beyond
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729272/
https://www.ncbi.nlm.nih.gov/pubmed/36505406
http://dx.doi.org/10.3389/fimmu.2022.1007823
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