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Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana

Cervical cancer burden is still high in low- and middle-income countries, including Botswana. Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer. Accurate knowledge of HPV diversity associated to cervical cancer in sub-Saharan Africa may provide accurate understa...

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Autores principales: Tawe, Leabaneng, Ramatlho, Pleasure, Ketlametswe, Rebecca, Koobotse, Moses, Robertson, Erle S., Grover, Surbhi, Ramogola-Masire, Doreen, Paganotti, Giacomo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729273/
https://www.ncbi.nlm.nih.gov/pubmed/36507502
http://dx.doi.org/10.3389/fmed.2022.1020760
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author Tawe, Leabaneng
Ramatlho, Pleasure
Ketlametswe, Rebecca
Koobotse, Moses
Robertson, Erle S.
Grover, Surbhi
Ramogola-Masire, Doreen
Paganotti, Giacomo M.
author_facet Tawe, Leabaneng
Ramatlho, Pleasure
Ketlametswe, Rebecca
Koobotse, Moses
Robertson, Erle S.
Grover, Surbhi
Ramogola-Masire, Doreen
Paganotti, Giacomo M.
author_sort Tawe, Leabaneng
collection PubMed
description Cervical cancer burden is still high in low- and middle-income countries, including Botswana. Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer. Accurate knowledge of HPV diversity associated to cervical cancer in sub-Saharan Africa may provide accurate understanding of the natural history of HPV infection in these contexts. The goal of this review was to consolidate existing evidence on cervical HPV infection and to conduct a pooled analysis of data from all eligible Botswana studies. After a successful review of twelve studies on cervical HPV genotypes that met the inclusion criteria, HPV-16 genotype was the most frequently discovered in women with pre-cancerous and cancer lesions, followed by HPV-18. HPV-16 in HIV-positive women with precancerous lesions to cancer is between 45% and 47.7%, and between 4.5% and 26.1% for HPV-18. With reference to other HPV genotypes, the proportion of HPV-35 and HPV-58 (13-16%) seems relatively consistent among the studies, however HPV-58 appears to be more common in HIV-positive subjects compared to HIV-negative women. Indeed, HPV-45 seems to be frequently detected in women with cervical cancer compared to women with precancerous lesions. Regarding the low-risk HPV genotypes, an appropriate breakdown has been provided. In conclusion, the current prophylactic vaccines against HPV-16 and HPV-18, which have demonstrated good immunogenicity in HIV-infected populations, may still prevent infection and ultimately cancer.
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spelling pubmed-97292732022-12-09 Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana Tawe, Leabaneng Ramatlho, Pleasure Ketlametswe, Rebecca Koobotse, Moses Robertson, Erle S. Grover, Surbhi Ramogola-Masire, Doreen Paganotti, Giacomo M. Front Med (Lausanne) Medicine Cervical cancer burden is still high in low- and middle-income countries, including Botswana. Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer. Accurate knowledge of HPV diversity associated to cervical cancer in sub-Saharan Africa may provide accurate understanding of the natural history of HPV infection in these contexts. The goal of this review was to consolidate existing evidence on cervical HPV infection and to conduct a pooled analysis of data from all eligible Botswana studies. After a successful review of twelve studies on cervical HPV genotypes that met the inclusion criteria, HPV-16 genotype was the most frequently discovered in women with pre-cancerous and cancer lesions, followed by HPV-18. HPV-16 in HIV-positive women with precancerous lesions to cancer is between 45% and 47.7%, and between 4.5% and 26.1% for HPV-18. With reference to other HPV genotypes, the proportion of HPV-35 and HPV-58 (13-16%) seems relatively consistent among the studies, however HPV-58 appears to be more common in HIV-positive subjects compared to HIV-negative women. Indeed, HPV-45 seems to be frequently detected in women with cervical cancer compared to women with precancerous lesions. Regarding the low-risk HPV genotypes, an appropriate breakdown has been provided. In conclusion, the current prophylactic vaccines against HPV-16 and HPV-18, which have demonstrated good immunogenicity in HIV-infected populations, may still prevent infection and ultimately cancer. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729273/ /pubmed/36507502 http://dx.doi.org/10.3389/fmed.2022.1020760 Text en Copyright © 2022 Tawe, Ramatlho, Ketlametswe, Koobotse, Robertson, Grover, Ramogola-Masire and Paganotti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Tawe, Leabaneng
Ramatlho, Pleasure
Ketlametswe, Rebecca
Koobotse, Moses
Robertson, Erle S.
Grover, Surbhi
Ramogola-Masire, Doreen
Paganotti, Giacomo M.
Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana
title Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana
title_full Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana
title_fullStr Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana
title_full_unstemmed Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana
title_short Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana
title_sort cervical human papillomavirus genotypes in a high hiv setting: a scoping review of a decade of human papillomavirus epidemiological research in botswana
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729273/
https://www.ncbi.nlm.nih.gov/pubmed/36507502
http://dx.doi.org/10.3389/fmed.2022.1020760
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