Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain

General anesthetics-induced neurotoxicity and cognitive impairment in developing brains have become one of the current research hotspots in the medical science community. The underlying mechanisms are complex and involve various related molecular signaling pathways, cell mediators, autophagy, and ot...

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Detalles Bibliográficos
Autores principales: Wang, Jiaojiao, Liu, Zhihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729288/
https://www.ncbi.nlm.nih.gov/pubmed/36504660
http://dx.doi.org/10.3389/fneur.2022.1065976
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author Wang, Jiaojiao
Liu, Zhihui
author_facet Wang, Jiaojiao
Liu, Zhihui
author_sort Wang, Jiaojiao
collection PubMed
description General anesthetics-induced neurotoxicity and cognitive impairment in developing brains have become one of the current research hotspots in the medical science community. The underlying mechanisms are complex and involve various related molecular signaling pathways, cell mediators, autophagy, and other pathological processes. However, few drugs can be directly used to treat neurotoxicity and cognitive impairment caused by general anesthetics in clinical practice. This article reviews the molecular mechanism of general anesthesia-induced neurotoxicity and cognitive impairment in the neonatal brain after surgery in the hope of providing critical references for the treatments of clinical diseases.
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spelling pubmed-97292882022-12-09 Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain Wang, Jiaojiao Liu, Zhihui Front Neurol Neurology General anesthetics-induced neurotoxicity and cognitive impairment in developing brains have become one of the current research hotspots in the medical science community. The underlying mechanisms are complex and involve various related molecular signaling pathways, cell mediators, autophagy, and other pathological processes. However, few drugs can be directly used to treat neurotoxicity and cognitive impairment caused by general anesthetics in clinical practice. This article reviews the molecular mechanism of general anesthesia-induced neurotoxicity and cognitive impairment in the neonatal brain after surgery in the hope of providing critical references for the treatments of clinical diseases. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729288/ /pubmed/36504660 http://dx.doi.org/10.3389/fneur.2022.1065976 Text en Copyright © 2022 Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wang, Jiaojiao
Liu, Zhihui
Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain
title Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain
title_full Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain
title_fullStr Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain
title_full_unstemmed Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain
title_short Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain
title_sort research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729288/
https://www.ncbi.nlm.nih.gov/pubmed/36504660
http://dx.doi.org/10.3389/fneur.2022.1065976
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