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Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy

Pathological complete response (pCR) after neoadjuvant chemotherapy (NCT) is associated with good long-term prognosis in breast cancer (BC) patients. However, some patients still recur and eventually die from this disease. For years, clinical stage at diagnosis has been consistently linked to recurr...

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Autores principales: Acevedo, Francisco, Walbaum, Benjamín, Muñiz, Sabrina, Petric, Militza, Martínez, Raúl, Guerra, Constanza, Navarro, Marisel, Córdova-Delgado, Miguel, Pinto, Mauricio P., Sánchez, Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729290/
https://www.ncbi.nlm.nih.gov/pubmed/36477462
http://dx.doi.org/10.1038/s41598-022-25043-2
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author Acevedo, Francisco
Walbaum, Benjamín
Muñiz, Sabrina
Petric, Militza
Martínez, Raúl
Guerra, Constanza
Navarro, Marisel
Córdova-Delgado, Miguel
Pinto, Mauricio P.
Sánchez, Cesar
author_facet Acevedo, Francisco
Walbaum, Benjamín
Muñiz, Sabrina
Petric, Militza
Martínez, Raúl
Guerra, Constanza
Navarro, Marisel
Córdova-Delgado, Miguel
Pinto, Mauricio P.
Sánchez, Cesar
author_sort Acevedo, Francisco
collection PubMed
description Pathological complete response (pCR) after neoadjuvant chemotherapy (NCT) is associated with good long-term prognosis in breast cancer (BC) patients. However, some patients still recur and eventually die from this disease. For years, clinical stage at diagnosis has been consistently linked to recurrence and survival in the pCR setting. Herein, we aimed to identify other potential predictors of recurrence and survival in patients that achieved pCR. We performed a retrospective analysis of patients diagnosed between 2011 and 2020 in our center. We calculated overall survival (OS), invasive disease-free survival (IDFS), distant disease-free survival (DDFS), and BC-specific survival (BCSS). Among the 241 patients included into our study 36% were obese (Body Mass Index (BMI) > 29.9 kg/m(2)) and 47% were stage III. Multivariate analysis confirmed that obesity was a significant risk factor associated with early recurrence and poorer survival in these patients. In summary, obesity and clinical stage predict early recurrence and poorer survival in patients that achieved pCR after NCT. Pending further investigation and based on our findings we speculate that weight management could be beneficial for this subset of patients. To our knowledge, this is the first Latin American report linking obesity and recurrence within this setting.
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spelling pubmed-97292902022-12-09 Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy Acevedo, Francisco Walbaum, Benjamín Muñiz, Sabrina Petric, Militza Martínez, Raúl Guerra, Constanza Navarro, Marisel Córdova-Delgado, Miguel Pinto, Mauricio P. Sánchez, Cesar Sci Rep Article Pathological complete response (pCR) after neoadjuvant chemotherapy (NCT) is associated with good long-term prognosis in breast cancer (BC) patients. However, some patients still recur and eventually die from this disease. For years, clinical stage at diagnosis has been consistently linked to recurrence and survival in the pCR setting. Herein, we aimed to identify other potential predictors of recurrence and survival in patients that achieved pCR. We performed a retrospective analysis of patients diagnosed between 2011 and 2020 in our center. We calculated overall survival (OS), invasive disease-free survival (IDFS), distant disease-free survival (DDFS), and BC-specific survival (BCSS). Among the 241 patients included into our study 36% were obese (Body Mass Index (BMI) > 29.9 kg/m(2)) and 47% were stage III. Multivariate analysis confirmed that obesity was a significant risk factor associated with early recurrence and poorer survival in these patients. In summary, obesity and clinical stage predict early recurrence and poorer survival in patients that achieved pCR after NCT. Pending further investigation and based on our findings we speculate that weight management could be beneficial for this subset of patients. To our knowledge, this is the first Latin American report linking obesity and recurrence within this setting. Nature Publishing Group UK 2022-12-07 /pmc/articles/PMC9729290/ /pubmed/36477462 http://dx.doi.org/10.1038/s41598-022-25043-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Acevedo, Francisco
Walbaum, Benjamín
Muñiz, Sabrina
Petric, Militza
Martínez, Raúl
Guerra, Constanza
Navarro, Marisel
Córdova-Delgado, Miguel
Pinto, Mauricio P.
Sánchez, Cesar
Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
title Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
title_full Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
title_fullStr Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
title_full_unstemmed Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
title_short Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
title_sort obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729290/
https://www.ncbi.nlm.nih.gov/pubmed/36477462
http://dx.doi.org/10.1038/s41598-022-25043-2
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