Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants

AIMS/HYPOTHESIS: TCF7L2 variants are the strongest genetic risk factor for type 2 diabetes. In individuals with type 1 diabetes, these variants are associated with a higher C-peptide AUC, a lower glucose AUC during an OGTT, single autoantibody positivity near diagnosis, particularly in individuals o...

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Detalles Bibliográficos
Autores principales: Redondo, Maria J., Richardson, Sarah J., Perry, Daniel, Minard, Charles G., Carr, Alice L. J., Brusko, Todd, Kusmartseva, Irina, Pugliese, Alberto, Atkinson, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729318/
https://www.ncbi.nlm.nih.gov/pubmed/36282337
http://dx.doi.org/10.1007/s00125-022-05818-y

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