Role of peripheral immune cells in spinal cord injury

Secondary spinal cord injury is caused by an inflammatory response cascade, and the process is irreversible. The immune system, as a mediator of inflammation, plays an important role in spinal cord injury. The spinal cord retains its immune privilege in a physiological state. Hence, elucidating the...

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Autores principales: Li, Cong, Xiong, Wu, Wan, Bowen, Kong, Guang, Wang, Siming, Wang, Yingying, Fan, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729325/
https://www.ncbi.nlm.nih.gov/pubmed/36478290
http://dx.doi.org/10.1007/s00018-022-04644-0
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author Li, Cong
Xiong, Wu
Wan, Bowen
Kong, Guang
Wang, Siming
Wang, Yingying
Fan, Jin
author_facet Li, Cong
Xiong, Wu
Wan, Bowen
Kong, Guang
Wang, Siming
Wang, Yingying
Fan, Jin
author_sort Li, Cong
collection PubMed
description Secondary spinal cord injury is caused by an inflammatory response cascade, and the process is irreversible. The immune system, as a mediator of inflammation, plays an important role in spinal cord injury. The spinal cord retains its immune privilege in a physiological state. Hence, elucidating the mechanisms by which peripheral immune cells are recruited to the lesion site and function after spinal cord injury is meaningful for the exploration of clinical therapeutic targets. In this review, we provide an overview of the multifaceted roles of peripheral immune cells in spinal cord injury.
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spelling pubmed-97293252022-12-09 Role of peripheral immune cells in spinal cord injury Li, Cong Xiong, Wu Wan, Bowen Kong, Guang Wang, Siming Wang, Yingying Fan, Jin Cell Mol Life Sci Review Secondary spinal cord injury is caused by an inflammatory response cascade, and the process is irreversible. The immune system, as a mediator of inflammation, plays an important role in spinal cord injury. The spinal cord retains its immune privilege in a physiological state. Hence, elucidating the mechanisms by which peripheral immune cells are recruited to the lesion site and function after spinal cord injury is meaningful for the exploration of clinical therapeutic targets. In this review, we provide an overview of the multifaceted roles of peripheral immune cells in spinal cord injury. Springer International Publishing 2022-12-07 2023 /pmc/articles/PMC9729325/ /pubmed/36478290 http://dx.doi.org/10.1007/s00018-022-04644-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Li, Cong
Xiong, Wu
Wan, Bowen
Kong, Guang
Wang, Siming
Wang, Yingying
Fan, Jin
Role of peripheral immune cells in spinal cord injury
title Role of peripheral immune cells in spinal cord injury
title_full Role of peripheral immune cells in spinal cord injury
title_fullStr Role of peripheral immune cells in spinal cord injury
title_full_unstemmed Role of peripheral immune cells in spinal cord injury
title_short Role of peripheral immune cells in spinal cord injury
title_sort role of peripheral immune cells in spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729325/
https://www.ncbi.nlm.nih.gov/pubmed/36478290
http://dx.doi.org/10.1007/s00018-022-04644-0
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