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Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy

INTRODUCTION: Central and peripheral nervous systems are all involved in type 2 diabetic polyneuropathy mechanisms, but such subclinical changes and associations remain unknown. This study aims to explore subclinical changes of the central and peripheral and unveil their association. METHODS: A tota...

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Autores principales: Zhao, Lin-Mei, Chen, Xin, Zhang, You-Ming, Qu, Min-Li, Selvarajah, Dinesh, Tesfaye, Solomon, Yang, Fang-Xue, Ou, Chu-Ying, Liao, Wei-Hua, Wu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729333/
https://www.ncbi.nlm.nih.gov/pubmed/36506054
http://dx.doi.org/10.3389/fendo.2022.1069437
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author Zhao, Lin-Mei
Chen, Xin
Zhang, You-Ming
Qu, Min-Li
Selvarajah, Dinesh
Tesfaye, Solomon
Yang, Fang-Xue
Ou, Chu-Ying
Liao, Wei-Hua
Wu, Jing
author_facet Zhao, Lin-Mei
Chen, Xin
Zhang, You-Ming
Qu, Min-Li
Selvarajah, Dinesh
Tesfaye, Solomon
Yang, Fang-Xue
Ou, Chu-Ying
Liao, Wei-Hua
Wu, Jing
author_sort Zhao, Lin-Mei
collection PubMed
description INTRODUCTION: Central and peripheral nervous systems are all involved in type 2 diabetic polyneuropathy mechanisms, but such subclinical changes and associations remain unknown. This study aims to explore subclinical changes of the central and peripheral and unveil their association. METHODS: A total of 55 type-2 diabetes patients consisting of symptomatic (n = 23), subclinical (n = 12), and no polyneuropathy (n = 20) were enrolled in this study. Cerebral morphology, function, peripheral electrophysiology, and clinical information were collected and assessed using ANOVA and post-hoc analysis. Gaussian random field correction was used for multiple comparison corrections. Pearson/Spearman correlation analysis was used to evaluate the association of the cerebral with the peripheral. RESULTS: When comparing the subclinical group with no polyneuropathy groups, no statistical differences were shown in peripheral evaluations except amplitudes of tibial nerves. At the same time, functional connectivity from the orbitofrontal to bilateral postcentral and middle temporal cortex increased significantly. Gray matter volume of orbitofrontal and its functional connectivity show a transient elevation in the subclinical group compared with the symptomatic group. Besides, gray matter volume in the orbitofrontal cortex negatively correlated with the Neuropathy Symptom Score (r = -0.5871, p < 0.001), Neuropathy Disability Score (r = -0.3682, p = 0.009), and Douleur Neuropathique en 4 questions (r = -0.4403, p = 0.003), and also found correlated positively with bilateral peroneal amplitude (r > 0.4, p < 0.05) and conduction velocities of the right sensory sural nerve(r = 0.3181, p = 0.03). Similarly, functional connectivity from the orbitofrontal to the postcentral cortex was positively associated with cold detection threshold (r = 0.3842, p = 0.03) and negatively associated with Neuropathy Symptom Score (r = -0.3460, p = 0.01). DISCUSSION: Function and morphology of brain changes in subclinical type 2 diabetic polyneuropathy might serve as an earlier biomarker. Novel insights from subclinical stage to investigate the mechanism of type 2 diabetic polyneuropathy are warranted.
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spelling pubmed-97293332022-12-09 Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy Zhao, Lin-Mei Chen, Xin Zhang, You-Ming Qu, Min-Li Selvarajah, Dinesh Tesfaye, Solomon Yang, Fang-Xue Ou, Chu-Ying Liao, Wei-Hua Wu, Jing Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Central and peripheral nervous systems are all involved in type 2 diabetic polyneuropathy mechanisms, but such subclinical changes and associations remain unknown. This study aims to explore subclinical changes of the central and peripheral and unveil their association. METHODS: A total of 55 type-2 diabetes patients consisting of symptomatic (n = 23), subclinical (n = 12), and no polyneuropathy (n = 20) were enrolled in this study. Cerebral morphology, function, peripheral electrophysiology, and clinical information were collected and assessed using ANOVA and post-hoc analysis. Gaussian random field correction was used for multiple comparison corrections. Pearson/Spearman correlation analysis was used to evaluate the association of the cerebral with the peripheral. RESULTS: When comparing the subclinical group with no polyneuropathy groups, no statistical differences were shown in peripheral evaluations except amplitudes of tibial nerves. At the same time, functional connectivity from the orbitofrontal to bilateral postcentral and middle temporal cortex increased significantly. Gray matter volume of orbitofrontal and its functional connectivity show a transient elevation in the subclinical group compared with the symptomatic group. Besides, gray matter volume in the orbitofrontal cortex negatively correlated with the Neuropathy Symptom Score (r = -0.5871, p < 0.001), Neuropathy Disability Score (r = -0.3682, p = 0.009), and Douleur Neuropathique en 4 questions (r = -0.4403, p = 0.003), and also found correlated positively with bilateral peroneal amplitude (r > 0.4, p < 0.05) and conduction velocities of the right sensory sural nerve(r = 0.3181, p = 0.03). Similarly, functional connectivity from the orbitofrontal to the postcentral cortex was positively associated with cold detection threshold (r = 0.3842, p = 0.03) and negatively associated with Neuropathy Symptom Score (r = -0.3460, p = 0.01). DISCUSSION: Function and morphology of brain changes in subclinical type 2 diabetic polyneuropathy might serve as an earlier biomarker. Novel insights from subclinical stage to investigate the mechanism of type 2 diabetic polyneuropathy are warranted. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729333/ /pubmed/36506054 http://dx.doi.org/10.3389/fendo.2022.1069437 Text en Copyright © 2022 Zhao, Chen, Zhang, Qu, Selvarajah, Tesfaye, Yang, Ou, Liao and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhao, Lin-Mei
Chen, Xin
Zhang, You-Ming
Qu, Min-Li
Selvarajah, Dinesh
Tesfaye, Solomon
Yang, Fang-Xue
Ou, Chu-Ying
Liao, Wei-Hua
Wu, Jing
Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy
title Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy
title_full Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy
title_fullStr Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy
title_full_unstemmed Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy
title_short Changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy
title_sort changed cerebral function and morphology serve as neuroimaging evidence for subclinical type 2 diabetic polyneuropathy
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729333/
https://www.ncbi.nlm.nih.gov/pubmed/36506054
http://dx.doi.org/10.3389/fendo.2022.1069437
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