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Application of herbal traditional Chinese medicine in the treatment of lupus nephritis

Lupus nephritis (LN) is a secondary renal disease caused by systemic lupus erythematosus affecting the kidneys. It is one of the main causes of end-stage renal disease and a serious risk factor for early mortality and disability of systemic lupus erythematosus patients. Existing LN treatment is main...

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Detalles Bibliográficos
Autores principales: Liu, Liu, Zhang, Lei, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729561/
https://www.ncbi.nlm.nih.gov/pubmed/36506523
http://dx.doi.org/10.3389/fphar.2022.981063
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author Liu, Liu
Zhang, Lei
Li, Ming
author_facet Liu, Liu
Zhang, Lei
Li, Ming
author_sort Liu, Liu
collection PubMed
description Lupus nephritis (LN) is a secondary renal disease caused by systemic lupus erythematosus affecting the kidneys. It is one of the main causes of end-stage renal disease and a serious risk factor for early mortality and disability of systemic lupus erythematosus patients. Existing LN treatment is mainly based on hormones, cytotoxic drugs, and biological agents. Nevertheless, the prognosis of LN patients remains poor because of frequent recurrence and exacerbation of adverse drug reactions. Hence, LN is still the most important cause of end-stage renal disease. In recent years, traditional Chinese medicine (TCM) has attracted increasing attention because of encouraging evidence that it alleviates LN and the well-described mechanisms underlying renal injury. TCM has therapeutic benefits for treating LN patients. This review article elucidates TCM preparations, TCM monomers, and herbal or natural extraction for LN treatment to provide effective supplementary evidence for promoting the development of TCM treatment for LN and reference for future research and clinical practice.
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spelling pubmed-97295612022-12-09 Application of herbal traditional Chinese medicine in the treatment of lupus nephritis Liu, Liu Zhang, Lei Li, Ming Front Pharmacol Pharmacology Lupus nephritis (LN) is a secondary renal disease caused by systemic lupus erythematosus affecting the kidneys. It is one of the main causes of end-stage renal disease and a serious risk factor for early mortality and disability of systemic lupus erythematosus patients. Existing LN treatment is mainly based on hormones, cytotoxic drugs, and biological agents. Nevertheless, the prognosis of LN patients remains poor because of frequent recurrence and exacerbation of adverse drug reactions. Hence, LN is still the most important cause of end-stage renal disease. In recent years, traditional Chinese medicine (TCM) has attracted increasing attention because of encouraging evidence that it alleviates LN and the well-described mechanisms underlying renal injury. TCM has therapeutic benefits for treating LN patients. This review article elucidates TCM preparations, TCM monomers, and herbal or natural extraction for LN treatment to provide effective supplementary evidence for promoting the development of TCM treatment for LN and reference for future research and clinical practice. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9729561/ /pubmed/36506523 http://dx.doi.org/10.3389/fphar.2022.981063 Text en Copyright © 2022 Liu, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Liu
Zhang, Lei
Li, Ming
Application of herbal traditional Chinese medicine in the treatment of lupus nephritis
title Application of herbal traditional Chinese medicine in the treatment of lupus nephritis
title_full Application of herbal traditional Chinese medicine in the treatment of lupus nephritis
title_fullStr Application of herbal traditional Chinese medicine in the treatment of lupus nephritis
title_full_unstemmed Application of herbal traditional Chinese medicine in the treatment of lupus nephritis
title_short Application of herbal traditional Chinese medicine in the treatment of lupus nephritis
title_sort application of herbal traditional chinese medicine in the treatment of lupus nephritis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729561/
https://www.ncbi.nlm.nih.gov/pubmed/36506523
http://dx.doi.org/10.3389/fphar.2022.981063
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